Urinary cyclophosphamide excretion and micronuclei frequencies in peripheral lymphocytes and in exfoliated buccal epithelial cells of nurses handling antineoplastics.
| Title: | Urinary cyclophosphamide excretion and micronuclei frequencies in peripheral lymphocytes and in exfoliated buccal epithelial cells of nurses handling antineoplastics. |
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| Authors: | Burgaz S; Department of Toxicology, Faculty of Pharmacy, Gazi University, Hipodrom, 06330, Ankara, Turkey.; Karahalil B; Bayrak P; Taşkin L; Yavuzaslan F; Bökesoy I; Anzion RB; Bos RP; Platin N |
| Source: | Mutation research [Mutat Res] 1999 Feb 02; Vol. 439 (1), pp. 97-104. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0400763 Publication Model: Print Cited Medium: Print ISSN: 0027-5107 (Print) Linking ISSN: 00275107 NLM ISO Abbreviation: Mutat Res Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Amsterdam : Elsevier, [1964- |
| MeSH Terms: | Antineoplastic Agents/*toxicity ; Cyclophosphamide/*urine ; Lymphocytes/*cytology ; Micronuclei, Chromosome-Defective/*drug effects ; Mouth Mucosa/*cytology ; Nurses/*statistics & numerical data; Lymphocytes/drug effects ; Micronuclei, Chromosome-Defective/genetics ; Mouth Mucosa/drug effects ; Occupational Exposure/statistics & numerical data ; Adult ; Age Factors ; Female ; Humans ; Sex Factors ; Smoking ; Turkey |
| Abstract: | In this study, urinary cyclophosphamide (CP) excretion rate, as well as micronuclei (MN) in peripheral lymphocytes and in buccal epithelial cells were determined for 26 nurses handling antineoplastics and 14 referents matched for age and sex. In urine samples of 20 out of 25 exposed nurses CP excretion rate was found in a range of 0.02-9.14 microg CP/24 h. Our results of the analyses of CP in urine demonstrates that when the nurses were handling CP (and other antineoplastic drugs) this particular compound was observed in urine. The mean values (+/-SD) of MN frequencies (%) in peripheral lymphocytes from the nurses and controls were 0.61 (+/-0. 32) and 0.28 (+/-0.16), respectively (p0.05). Age, sex and smoking habits have not influenced the parameters analyzed in this study. Handling time of antineoplastics, use of protective equipment and handling frequency of drugs have no effect on urinary and cytogenetic parameters analyzed. No correlation was found between the urinary CP excretion and the cytogenetic findings in nurses. Neither could we find any relationship between two cytogenetic endpoints. Our results have identified the possible genotoxic damage of oncology nurses related to occupational exposure to at least one antineoplastic agent, which is used as a marker for drug handling. As a whole, there is concern that the present handling practices of antineoplastic drugs used in the several hospitals in Ankara will not be sufficient to prevent exposure.; (Copyright 1999 Elsevier Science B.V.) |
| Substance Nomenclature: | 0 (Antineoplastic Agents); 8N3DW7272P (Cyclophosphamide) |
| Entry Date(s): | Date Created: 19990225 Date Completed: 19990329 Latest Revision: 20190702 |
| Update Code: | 20260130 |
| DOI: | 10.1016/s1383-5718(98)00180-6 |
| PMID: | 10029685 |
| Database: | MEDLINE |
Journal Article; Research Support, Non-U.S. Gov't