| Title: |
Prevalence and risk factors for High-Risk Human Papillomavirus (hrHPV) infection among HIV-infected and Uninfected Rwandan women: implications for hrHPV-based screening in Rwanda. |
| Authors: |
Sinayobye, Jean d¿Amour; Sklar, Marc; Hoover, Donald R.; Qiuhu Shi; Dusingize, Jean Claude; Cohen, Mardge; Mutimura, Eugene; Asiimwe-Kateera, Brenda; Castle, Philip E.; Strickler, Howard; Anastos, Kathryn |
| Source: |
Infectious Agents & Cancer; 2014, Vol. 9 Issue 1, p1-27, 27p, 1 Diagram, 5 Charts, 1 Graph |
| Subject Terms: |
HIV infections; PAPILLOMAVIRUS diseases; PAPILLOMAVIRUSES; CERVIX uteri tumors; DISEASE prevalence; EARLY detection of cancer |
| Geographic Terms: |
RWANDA |
| Abstract: |
Background New World Health Organization guidelines recommend high-risk human papillomavirus (hrHPV) screen-and-treat strategies for cervical cancer prevention. We describe risk of, and risk factors for, testing hrHPV positive in a pilot study of hrHPV screen-and-treat conducted in Rwanda. Methods A total of 2,964 women, 1,289 HIV-infected (HIV [+]) and 1,675 HIV-uninfected (HIV [-]), aged 30-60 years and living in Rwanda were enrolled in 2010. Cervical specimens were collected and tested by careHPV, a DNA test for a pool of 14 hrHPV types. Prevalence with binomial 95% confidence intervals (95%CI) and determinants of testing hrHPV positive were calculated. Results hrHPV prevalence was higher in HIV [+] (31.8%, 95%CI = 29.2-34.4%) than HIV [-] women (8.2%, 95%CI = 6.7-9.8%; P < 0.0001). Among HIV [+] women, there was a significant trend (ptrend |
| : |
Copyright of Infectious Agents & Cancer is the property of BioMed Central and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Complementary Index |