| Title: |
Promoter methylation analysis of SIRT3, SMARCA5, HTERT and CDH1 genes in aging and Alzheimer's disease. |
| Authors: |
Silva PN; Gigek CO; Leal MF; Bertolucci PH; de Labio RW; Payao SL; Smith Mde A; Silva, Patrícia Natália Oliveira; Gigek, Carolina Oliveira; Leal, Mariana Ferreira; Bertolucci, Paulo Henrique Ferreira; de Labio, Roger Willian; Payão, Spencer Luiz Marques; Smith, Marília de Arruda Cardoso |
| Source: |
Journal of Alzheimer's Disease; 2008, Vol. 13 Issue 2, p173-176, 4p |
| Abstract: |
Longevity related genes were investigated concerning promoter methylation. SIRT3, SMARCA5, HTERT and CDH1 promoters were analyzed in peripheral blood in relation to gender, age and Alzheimer's disease (AD). Methylation Specific PCR assay (MSP) was used. There were no significant differences in methylation frequencies of SIRT3, SMARCA5 and CDH1 among young, elderly and AD groups (p> 0.05), showing no association with aging or AD. On the other hand, HTERT methylation frequency was associated with the aging process, in that AD patients differed from elderly controls (p=0.0086), probably due to telomere and immune dysfunctions involved in AD pathogenesis. [ABSTRACT FROM AUTHOR] |
| : |
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| Database: |
Complementary Index |