| Title: |
Measuring flushing symptoms with extended-release niacin using the flushing symptom questionnaire: results from a randomised placebo-controlled clinical trial. |
| Authors: |
Paolini JF; Mitchel YB; Reyes R; Thompson-Bell S; Yu Q; Lai E; Watson DJ; Norquist JM; Sisk CM; Bays HE; Paolini, J F; Mitchel, Y B; Reyes, R; Thompson-Bell, S; Yu, Q; Lai, E; Watson, D J; Norquist, J M; Sisk, C McCrary; Bays, H E |
| Source: |
International Journal of Clinical Practice; Jun2008, Vol. 62 Issue 6, p896-904, 9p |
| Abstract: |
Introduction: Niacin is underutilised because of flushing. Lack of a quantitative tool to assess niacin-induced flushing has precluded the objective evaluation of flushing associated with extended-release (ER) niacin formulations. We developed the Flushing Symptom Questionnaire((c)) (FSQ), a quantitative tool to assess patient-reported flushing, and assessed its ability to characterise ER niacin-induced flushing.Methods: This study focused on the responses to one question in the FSQ, the Global Flushing Severity Score (GFSS), reported on a 0-10 scale (none = 0, mild = 1-3, moderate = 4-6, severe = 7-9 and extreme = 10) to assess flushing during ER niacin initiation (week 1) and maintenance (weeks 2-8).Results: Flushing severity with ER niacin was greatest during week 1 and remained greater than placebo for the study duration. During weeks 2-8, 40% of patients on ER niacin vs. 8% of those on placebo had > 1 day/week with 'moderate or greater' GFSS.Conclusions: In conclusion, the GFSS component of the FSQ was a sensitive and responsive quantitative measure of ER niacin-induced flushing that will aid in the objective comparison of novel strategies intended to improve tolerability and adherence to niacin, an agent proven to reduce cardiovascular risk. [ABSTRACT FROM AUTHOR] |
| : |
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| Database: |
Complementary Index |