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Efficacy of inhaled insulin in patients with type 2 diabetes not controlled with diet and exercise: a 12-week, randomized, comparative trial.

Title: Efficacy of inhaled insulin in patients with type 2 diabetes not controlled with diet and exercise: a 12-week, randomized, comparative trial.
Authors: DeFronzo RA; Bergenstal RM; Cefalu WT; Pullman J; Lerman S; Bode BW; Phillips LS; Exubera Phase III Study Group; DeFronzo, Ralph A; Bergenstal, Richard M; Cefalu, William T; Pullman, John; Lerman, Sam; Bode, Bruce W; Phillips, Lawrence S
Source: Diabetes Care; Aug2005, Vol. 28 Issue 8, p1922-1928, 7p
Abstract: Objective: Effective type 2 diabetes management requires prompt intervention if glycemic control is not achieved by nonpharmacological means. This study investigates whether inhaled insulin (INH; Exubera) can achieve target glycemic control in patients failing on diet and exercise.Research Design and Methods: Patients with suboptimal control on diet and exercise (HbA(1c) [A1C] 8-11%) were randomized to 3 months' treatment with either INH before meals (n = 76) or rosiglitazone 4 mg twice a day (n = 69), in conjunction with a diet and exercise regimen. The primary end point was percentage of patients achieving A1C
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Database: Complementary Index