[Association between elevated serum VEGF and polarographically measured tumor hypoxia in head and neck carcinomas].
| Title: | [Association between elevated serum VEGF and polarographically measured tumor hypoxia in head and neck carcinomas]. |
|---|---|
| Transliterated Title: | Assoziation zwischen erhöhten Serum-VEGF-Werten und polarographisch gemessener Tumorhypoxie bei Patienten mit Kopf-Hals-Karzinomen. |
| Authors: | Becker A; Institut für Biometrie, Martin-Luther-Universität Halle-Wittenberg. axel.becker@medizin.uni-halle.de; Stadler P; Krause U; Utzig D; Hänsgen G; Lautenschläger C; Rath FW; Molls M; Dunst J |
| Source: | Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] [Strahlenther Onkol] 2001 Apr; Vol. 177 (4), pp. 182-8. |
| Publication Type: | English Abstract; Journal Article |
| Language: | German |
| Journal Info: | Publisher: Urban & Vogel Country of Publication: Germany NLM ID: 8603469 Publication Model: Print Cited Medium: Print ISSN: 0179-7158 (Print) Linking ISSN: 01797158 NLM ISO Abbreviation: Strahlenther Onkol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [München] : Urban & Vogel, [c1986- |
| MeSH Terms: | Cell Hypoxia* ; Polarography*; Endothelial Growth Factors/*blood ; Head and Neck Neoplasms/*metabolism ; Lymphokines/*blood ; Oxygen/*metabolism; Head and Neck Neoplasms/blood ; Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Platelet Count ; Risk ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factors |
| Abstract: | Purpose: Clinical investigation of a potential relationship between VEGF concentration in serum (sVEGF) and polarographically measured tumor oxygenation in patients with squamous cell carcinoma of the head and neck (SCCHN).; Patients and Methods: In 56 patients with SCCHN we estimated the classical tumor parameters, the sVEGF concentration (immunoassay) and the tumor oxygenation (Eppendorf pO2 histograph). The platelet count and the tumor volume were evaluated simultaneously.; Results: In a unifactorial analysis the total volume (132 cm3 vs. 38 cm3), the hypoxic subvolume (HSV = total volume multiplied with the relative frequency of values < or=5 mm Hg/63 cm3 vs. 10 cm3) and the platelet count (380 10(9)/l vs. 271 10(9)/l) were significantly higher in the patient group with a sVEGF level > 707 pg/ml compared to the group with a sVEGF below this threshold. The multifactorial analysis confirmed significant effects for the hypoxic subvolume and the platelet count. Regarding hypoxic subvolume and sVEGF as continuous parameters a significantly positive correlation was found. This correlation remained somewhat weaker but significant after inclusion of the platelet count as covariate.; Conclusion: On base of our data a clinical association between elevated sVEGF and polarographically measured tumor hypoxia could be confirmed. This was possible considering not only the relative grade of hypoxia but also the absolute amount of hypoxic regions. The VEGF released from platelets during blood clotting influences the sVEGF level essentially, however, the hypoxia effect was not completely deleted. Due to the platelet effect an estimation of sVEGF is not able to substitute polarographical measurement of tumor pO2. Therefore in an ongoing study we investigate whether VEGF values estimated in plasma are better correlated with the polarographically measured tumor pO2 than serum VEGF levels. |
| Substance Nomenclature: | 0 (Endothelial Growth Factors); 0 (Lymphokines); 0 (Vascular Endothelial Growth Factor A); 0 (Vascular Endothelial Growth Factors); S88TT14065 (Oxygen) |
| Entry Date(s): | Date Created: 20010524 Date Completed: 20010531 Latest Revision: 20131121 |
| Update Code: | 20260130 |
| PMID: | 11370552 |
| Database: | MEDLINE |
English Abstract; Journal Article