Clinical significance of the dispersion of the activation--recovery interval and recovery time as markers for ventricular fibrillation susceptibility in patients with Brugada syndrome.
| Title: | Clinical significance of the dispersion of the activation--recovery interval and recovery time as markers for ventricular fibrillation susceptibility in patients with Brugada syndrome. |
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| Authors: | Nanke T; Department of Internal Medicine, St Marianna University School of Medicine, Kawasaki, Japan. t2nanke@marianna-u.ac.jp; Nakazawa K; Arai M; Ryuu S; Osada K; Sakurai T; Miyake F |
| Source: | Circulation journal : official journal of the Japanese Circulation Society [Circ J] 2002 Jun; Vol. 66 (6), pp. 549-52. |
| Publication Type: | Comparative Study; Journal Article |
| Language: | English |
| Journal Info: | Publisher: Japanese Circulation Society Country of Publication: Japan NLM ID: 101137683 Publication Model: Print Cited Medium: Print ISSN: 1346-9843 (Print) Linking ISSN: 13469843 NLM ISO Abbreviation: Circ J Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Kyoto, Japan : Japanese Circulation Society, [2002- |
| MeSH Terms: | Electrocardiography*; Arrhythmias, Cardiac/*complications ; Ventricular Fibrillation/*epidemiology ; Ventricular Fibrillation/*physiopathology; Biomarkers ; Death, Sudden, Cardiac ; Disease Susceptibility ; Heart Rate ; Humans ; Recurrence ; Reference Values |
| Abstract: | Brugada syndrome (BS) is associated with sudden cardiac death and the markers for ventricular fibrillation (VF) remain unclear, so the activation-recovery interval (ARI) dispersion and recovery time (RT) dispersion were investigated as possible markers in 20 subjects with BS (BS group) and 22 healthy individuals (H group). The 20 BS subjects were divided into 8 cases with documented VF (BS-VF group), 3 of which had recurrences, and 12 without (BS-N group). The corrected dispersion measurements from the standard 12-lead ECG of the QT interval (QTcd), ARI (ARIcd) and RT (RTcd) were compared among the groups. There were significant differences noted between the BS-VF and BS-N groups for the ARIcd and the RTcd, but not for the QTcd. Further, there were critical differences, 150 ms(1/2), observed for the ARIcd and RTcd, and these were associated with a prolongation of the maximum ARI or RT, shortening of the minimum ARI or RT, and prolongation only of the maximum QT for the QTcd. Susceptibility to VF may be predicted by the ARIcd or RTcd in BS. |
| Substance Nomenclature: | 0 (Biomarkers) |
| Entry Date(s): | Date Created: 20020621 Date Completed: 20021220 Latest Revision: 20190819 |
| Update Code: | 20260130 |
| DOI: | 10.1253/circj.66.549 |
| PMID: | 12074270 |
| Database: | MEDLINE |
Comparative Study; Journal Article