| Title: |
Adenylyl cyclase activating polypeptide reduces phosphorylation and toxicity of the polyglutamine-expanded androgen receptor in spinobulbar muscular atrophy. |
| Authors: |
Polanco, Maria Josè; Parodi, Sara; Piol, Diana; Stack, Conor; Chivet, Mathilde; Contestabile, Andrea; Miranda, Helen C.; Lievens, Patricia M.-J.; Espinoza, Stefano; Jochum, Tobias; Rocchi, Anna; Grunseich, Christopher; Gainetdinov, Raul R.; Cato, Andrew C. B.; Lieberman, Andrew P.; La Spada, Albert R.; Sambataro, Fabio; Fischbeck, Kenneth H.; Gozes, Illana; Pennuto, Maria |
| Source: |
Science Translational Medicine; 12/21/2016, Vol. 8 Issue 370, p1-16, 16p, 4 Color Photographs, 4 Graphs |
| Subject Terms: |
POLYGLUTAMINE; ANDROGEN receptors; PHOSPHORYLATION; PROTEIN kinases; JAK-STAT pathway |
| Abstract: |
This article presents a study on the development of a strategy to reduce polyglutamine-androgen receptor(AR) (polyQ-AR) accumulation and toxicity in degenerating cells by modulation of the AR phosphorylation state. It discusses a decrease in the accumulation of phosphorylated AR in neuronal cells by adenylyl cyclase/protein kinase A signaling pathway, and the effect of phosphorylation on aggregation and turnover of polyQ-AR. |
| Database: |
Complementary Index |