| Title: |
Postnatal glucocorticoids induce α-ENaC formation and regulate glucocorticoid receptors in the preterm rabbit lung. |
| Authors: |
Mustafa, Shamimunisa B.; DiGeronimo, Robert J.; Petershack, Jean A.; Alcorn, Joseph L.; Seidner, Steven R. |
| Source: |
American Journal of Physiology: Lung Cellular & Molecular Physiology; Jan2004, Vol. 30 Issue 1, pL73-L80, 8p, 11 Black and White Photographs, 7 Graphs |
| Subject Terms: |
Glucocorticoids; Lungs; Epithelial cells; Sodium channels; Gene expression; Laboratory rabbits; Cell receptors |
| Abstract: |
Presents a study that evaluated the effect of postnatal glucocorticoids (GC) on lung α-epithelial NA+ (ENaC) mRNA expression in preterm 29-day gestational age fetal rabbits. Postnatal treatment of GA fetuses with 0.5 milligram per kilogram of dexamethasone; Two- and 22-fold increase in lung α-ENaC mRNA expression compared with saline-treated counterparts; Glucocorticoid receptor antagonist RU-486 in fetal distal lung epithelial cells. |
| Database: |
Complementary Index |