Experimental study on the effectiveness and safety of radiofrequency catheter ablation with the cooled ablation system.
| Title: | Experimental study on the effectiveness and safety of radiofrequency catheter ablation with the cooled ablation system. |
|---|---|
| Authors: | Matsumoto N; Department of Pharmacology, St. Marianna University School of Medicine, Kawasaki, Japan.; Kishi R; Kasugai H; Sakurai T; Osada K; Ryu S; Arai M; Miyazu O; Watanabe Y; Kimura M; Nanke T; Nakazawa K; Kobayashi S; Miyake F |
| Source: | Circulation journal : official journal of the Japanese Circulation Society [Circ J] 2003 Feb; Vol. 67 (2), pp. 154-8. |
| Publication Type: | Evaluation Study; Journal Article |
| Language: | English |
| Journal Info: | Publisher: Japanese Circulation Society Country of Publication: Japan NLM ID: 101137683 Publication Model: Print Cited Medium: Print ISSN: 1346-9843 (Print) Linking ISSN: 13469843 NLM ISO Abbreviation: Circ J Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Kyoto, Japan : Japanese Circulation Society, [2002- |
| MeSH Terms: | Catheter Ablation/*instrumentation; Arrhythmias, Cardiac/therapy ; Burns/etiology ; Catheter Ablation/adverse effects ; Catheter Ablation/standards ; Coronary Vessels/injuries ; Myocardium/pathology ; Animals ; Dogs ; Equipment Design ; In Vitro Techniques ; Lung Injury ; Swine ; Temperature ; Treatment Outcome |
| Abstract: | Experimental in vitro and in vivo studies were performed to assess the effectiveness and safety of the cooled-tip catheter and the Cooled Ablation System, which enables the creation of deeper and wider burn lesions in the myocardial tissue using radiofrequency current. This system was confirmed to consistently create large burns by cooling the catheter tip with circulating water within the catheter, even under unfavorable conditions. On the other hand, unfavorable effects, as a result of over burning, such as explosive vaporization within the tissue (the 'pop' phenomenon), tissue carbonization, coronary artery injury and lung injury were identified. 'Pop' was difficult to predict, but it is important to know how it can be avoided. No 'Pop' was seen without first observing an impedance decrease, thus it was considered safe to decrease the radiofrequency current if the impedance began to decrease. This system will be very effective for ablation of refractory arrhythmias, such as ventricular tachycardia or atrial flutter, but it is recommended that only experienced electrophysiologists use this system to avoid serious complications. |
| Entry Date(s): | Date Created: 20030128 Date Completed: 20031003 Latest Revision: 20191210 |
| Update Code: | 20260130 |
| DOI: | 10.1253/circj.67.154 |
| PMID: | 12547999 |
| Database: | MEDLINE |
Evaluation Study; Journal Article