Autonomic imbalance as a property of symptomatic Brugada syndrome.
| Title: | Autonomic imbalance as a property of symptomatic Brugada syndrome. |
|---|---|
| Authors: | Nakazawa K; Division of Cardiology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan.; Sakurai T; Takagi A; Kishi R; Osada K; Nanke T; Miyake F; Matsumoto N; Kobayashi S |
| Source: | Circulation journal : official journal of the Japanese Circulation Society [Circ J] 2003 Jun; Vol. 67 (6), pp. 511-4. |
| Publication Type: | Comparative Study; Journal Article |
| Language: | English |
| Journal Info: | Publisher: Japanese Circulation Society Country of Publication: Japan NLM ID: 101137683 Publication Model: Print Cited Medium: Print ISSN: 1346-9843 (Print) Linking ISSN: 13469843 NLM ISO Abbreviation: Circ J Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Kyoto, Japan : Japanese Circulation Society, [2002- |
| MeSH Terms: | Autonomic Nervous System Diseases/*physiopathology ; Bundle-Branch Block/*physiopathology ; Death, Sudden, Cardiac/*etiology ; Heart Conduction System/*physiopathology ; Ventricular Fibrillation/*physiopathology; Cardiac Complexes, Premature/physiopathology ; Syncope/etiology ; Syncope/physiopathology ; Circadian Rhythm ; Electrocardiography, Ambulatory ; Heart Rate ; Humans ; Male ; Middle Aged ; Syndrome |
| Abstract: | The autonomic properties in 27 patients with the electrocardiographic morphology of Brugada syndrome were investigated using 24-h Holter monitoring: 10 patients had a history of ventricular fibrillation (VF; Br-VF group) and 17 did not (Br-N group); there were 26 healthy subjects enrolled in this study. All subjects underwent normal Holter data monitoring and power spectral analysis. Few extrasystoles were observed in either group, and the mean heart rate (HR), maximum HR, and total heart beats over 24 h were obtained. All of these measurements were significantly lower in the Br-VF group than in the Br-N and healthy subject groups. The RR interval variability was analyzed over 512 beats every 10 min. The high-frequency component (0.15-0.40 Hz; HF), low-frequency component (0.04-0.15 Hz; LF) and the LF/HF ratio were analyzed over 24 h. The HF was significantly higher and LF/HF ratio lower in the Br-VF group than in the healthy subjects. The HF was also significantly higher than in the Br-N group. During the night (00.00-05.00 h), the HF was significantly higher in the Br-VF group, and the LH/HF lower. During the day (12.00-17.00 h), the HF was significantly higher in the Br-VF group, but there was no difference in the LF/HF. These results indicate that high vagal tone and low sympathetic tone are specific properties of symptomatic Brugada syndrome. |
| Entry Date(s): | Date Created: 20030617 Date Completed: 20040123 Latest Revision: 20190819 |
| Update Code: | 20260130 |
| DOI: | 10.1253/circj.67.511 |
| PMID: | 12808268 |
| Database: | MEDLINE |
Comparative Study; Journal Article