| Title: |
Integrase strand transfer inhibitors and neuropsychiatric adverse events in a large prospective cohort. |
| Authors: |
Cuzin, Lise; Pugliese, Pascal; Katlama, Christine; Bani-Sadr, Firouzé; Ferry, Tristan; Rey, David; Lourenco, Jeremy; Bregigeon, Sylvie; Allavena, Clotilde; Reynes, Jacques; Cabié, André; Dat’AIDS Study Group |
| Source: |
Journal of Antimicrobial Chemotherapy (JAC); Mar2019, Vol. 74 Issue 3, p754-760, 7p |
| Subject Terms: |
INTEGRASES; NEUROBEHAVIORAL disorders; RALTEGRAVIR; ABACAVIR; NUCLEOSIDE reverse transcriptase inhibitors |
| Abstract: |
Objectives: To analyse the frequency and causes of treatment discontinuation in patients who were treated with an integrase strand transfer inhibitor (INSTI), with a focus on neuropsychiatric adverse events (NPAEs).Methods: Patients in 18 HIV reference centres in France were prospectively included in the Dat'AIDS cohort. Data were collected from all patients starting an INSTI-containing regimen between 1 January 2006 and 31 December 2016. All causes of INSTI-containing regimen discontinuations were analysed, and patients' characteristics related to discontinuation due to NPAEs were sought.Results: INSTIs were prescribed to 21315 patients: 6274 received dolutegravir, 3421 received elvitegravir boosted by cobicistat, and 11620 received raltegravir. Discontinuation was observed in 12.5%, 20.2% and 50.9% of the dolutegravir-, elvitegravir- and raltegravir-treated patients, respectively (P |
| : |
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| Database: |
Complementary Index |