[Oxidative stress and endothelial dysfunction].
| Title: | [Oxidative stress and endothelial dysfunction]. |
|---|---|
| Transliterated Title: | Oksidacinis stresas ir endotelio disfunkcija. |
| Authors: | Jarasūniene D; Klaipeda Seamen's Hospital, Liepojos 45, 5809 Klaipeda, Lithuania. dalijara@delfi.lt; Simaitis A |
| Source: | Medicina (Kaunas, Lithuania) [Medicina (Kaunas)] 2003; Vol. 39 (12), pp. 1151-7. |
| Publication Type: | Comparative Study; English Abstract; Journal Article; Review |
| Language: | Lithuanian |
| Journal Info: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 9425208 Publication Model: Print Cited Medium: Print ISSN: 1010-660X (Print) Linking ISSN: 1010660X NLM ISO Abbreviation: Medicina (Kaunas) Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2018- : Basel, Switzerland : MDPI; Original Publication: Kaunas : Lietuvos gydytojų sąjunga |
| MeSH Terms: | Oxidative Stress*; Arteriosclerosis/*etiology ; Endothelium, Vascular/*physiopathology; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Antihypertensive Agents/therapeutic use ; Antioxidants/therapeutic use ; Arteriosclerosis/physiopathology ; Arteriosclerosis/prevention & control ; Coronary Artery Disease/etiology ; Coronary Artery Disease/physiopathology ; Coronary Artery Disease/prevention & control ; Estrogens/therapeutic use ; Hyperlipidemias/complications ; Hyperlipidemias/drug therapy ; Hyperlipidemias/prevention & control ; Hypertension/complications ; Hypertension/drug therapy ; Hypolipidemic Agents/therapeutic use ; Mineralocorticoid Receptor Antagonists/therapeutic use ; Smoking/adverse effects ; Age Factors ; Animals ; Controlled Clinical Trials as Topic ; Diabetes Complications ; Disease Models, Animal ; Free Radicals ; Haplorhini ; Humans ; Multicenter Studies as Topic ; Placebos ; Risk Factors |
| Abstract: | Growing numbers of morbidity and mortality due to the Coronary Heart Disease (CHD) is recognized as the more increasing challenge in the world. The initial stage of atherosclerosis, early diagnosis and treatment of CHD are the main objectives of current research. Endothelium dysfunction, the earliest expression of the atherosclerotic process is associated with subtle biochemical changes that gradually are transformed into the structural changes of the arterial wall. The theory of free radicals is the most common among the atherosclerosis explanations. Overproduction or impaired neutralization of the free radicals accounts for oxidative stress that is causing substantial damage to the low density lipoproteins, nitric oxyde (NO), endothelium cells, tissue cells and finally leads to the endothelium dysfuction. Pathophysiology of oxidative stress and its role in the endothelium dysfunction are discussed in this paper. Positive role of various medications (statins, angiotensin converting enzym inhibitors, aldosteron antagonists, estrogens, antioxidants, b-blockers with vasodilatative properties) to the oxidative stress and consequently to the endothelium dysfuction are discussed as well. |
| Number of References: | 35 |
| Substance Nomenclature: | 0 (Angiotensin-Converting Enzyme Inhibitors); 0 (Antihypertensive Agents); 0 (Antioxidants); 0 (Estrogens); 0 (Free Radicals); 0 (Hypolipidemic Agents); 0 (Mineralocorticoid Receptor Antagonists); 0 (Placebos) |
| Entry Date(s): | Date Created: 20040106 Date Completed: 20040130 Latest Revision: 20180614 |
| Update Code: | 20260130 |
| PMID: | 14704502 |
| Database: | MEDLINE |
Comparative Study; English Abstract; Journal Article; Review