[Duodenal ulcers that do not heal for a long time].
| Title: | [Duodenal ulcers that do not heal for a long time]. |
|---|---|
| Transliterated Title: | O dolgo nezazhivaiushchikh iazvakh dvenadtsatisperstnoĭ kishki. |
| Authors: | Geller LI; Bessonova GA |
| Source: | Klinicheskaia meditsina [Klin Med (Mosk)] 1992 Feb; Vol. 70 (2), pp. 85-8. |
| Publication Type: | Comparative Study; English Abstract; Journal Article |
| Language: | Russian |
| Journal Info: | Publisher: Med. informat︠s︡ionnoe agentstvo Country of Publication: Russia (Federation) NLM ID: 2985204R Publication Model: Print Cited Medium: Print ISSN: 0023-2149 (Print) Linking ISSN: 00232149 NLM ISO Abbreviation: Klin Med (Mosk) Subsets: MEDLINE |
| Imprint Name(s): | Publication: Moskva : Med. informat︠s︡ionnoe agentstvo; Original Publication: Moskva. |
| MeSH Terms: | Antacids/*therapeutic use ; Anti-Ulcer Agents/*therapeutic use ; Duodenal Ulcer/*drug therapy; Aluminum Hydroxide/therapeutic use ; Benzocaine/therapeutic use ; Bismuth/therapeutic use ; Cimetidine/therapeutic use ; Duodenal Ulcer/pathology ; Magnesium Hydroxide/therapeutic use ; Sucralfate/therapeutic use ; Adult ; Drug Combinations ; Humans ; Time Factors ; Wound Healing |
| Abstract: | The investigations of 43 duodenal ulcer cases in the patients whose ulcers failed to cicatrize after a 8-week treatment with almagel and vicalin or cimetidine monotherapy revealed the role of the hereditary load, smoking intensity, initial ulcer dimensions, the presence of antral erosions and a pronounced periulcerous duodenitis in the phenomenon of slow healing duodenal ulcer. There was no statistical difference between the values of the basal and pentagastrin-stimulated levels of hydrochloric acid secretion in the morning, partial alkaline gastric secretion, gastrinemia, the rate of evacuation of the gastric contents into the duodenum, the outcome of pancreatic bicarbonates in the sample with exogenic secretin in those whose ulcers cicatrized after a 6-week therapy and those who failed to be cured after being exposed to the same therapy during 8 weeks. The production of hydrochloric acid in the evening and the incidence of manifest duodenal reflux were significantly higher in the patients with slowly healing ulcer. They also had a decreased sensitivity to the intraduodenal inflow of the hydrochloric acid that resulted in the increase of endogenic secretin (stimulating the production of pancreatic bicarbonates and their transport into the duodenum). In case the combination treatment with almagel and vicalin failed, the therapy with gastrocepin or sucralfate was employed. A supplementary course of sucralfate helped to reach a complete healing of noncomplicated ulcers even in the patients in whom the preceding cimetidine treatment failed. |
| Substance Nomenclature: | 0 (Antacids); 0 (Anti-Ulcer Agents); 0 (Drug Combinations); 0 (aluminum hydroxide, benzocaine, magnesium hydroxide drug combination); 54182-58-0 (Sucralfate); 5QB0T2IUN0 (Aluminum Hydroxide); 80061L1WGD (Cimetidine); H19J064BA5 (bismuth subnitrate); NBZ3QY004S (Magnesium Hydroxide); U015TT5I8H (Bismuth); U3RSY48JW5 (Benzocaine) |
| Entry Date(s): | Date Created: 19920201 Date Completed: 19920921 Latest Revision: 20151119 |
| Update Code: | 20260130 |
| PMID: | 1507833 |
| Database: | MEDLINE |
Comparative Study; English Abstract; Journal Article