[Relationship of paradoxical vasoconstriction induced by acetylcholine to risk factors for ischemic heart disease].
| Title: | [Relationship of paradoxical vasoconstriction induced by acetylcholine to risk factors for ischemic heart disease]. |
|---|---|
| Transliterated Title: | Paradoksines vazokonstrikcijos, sukeltos acetilcholino, rysys su isemines sirdies ligos rizikos faktoriais. |
| Authors: | Jarasūniene D; Klaipeda Seamen's Hospital, Liepojos 45, 5809 Klaipeda, Lithuania. dalijara@delfi.lt; Simaitis A |
| Source: | Medicina (Kaunas, Lithuania) [Medicina (Kaunas)] 2004; Vol. 40 Suppl 1, pp. 94-9. |
| Publication Type: | Comparative Study; English Abstract; Journal Article |
| Language: | Lithuanian |
| Journal Info: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 9425208 Publication Model: Print Cited Medium: Internet ISSN: 1648-9144 (Electronic) Linking ISSN: 1010660X NLM ISO Abbreviation: Medicina (Kaunas) Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2018- : Basel, Switzerland : MDPI; Original Publication: Kaunas : Lietuvos gydytojų sąjunga |
| MeSH Terms: | Acetylcholine*/administration & dosage ; Acetylcholine*/pharmacology ; Vasodilator Agents*/administration & dosage ; Vasodilator Agents*/pharmacology ; Vasoconstriction*; Endothelium, Vascular/*physiopathology ; Myocardial Ischemia/*diagnosis; Chest Pain/diagnosis ; Coronary Vessels/drug effects ; Hypercholesterolemia/complications ; Hypertension/complications ; Myocardial Ischemia/etiology ; Smoking/adverse effects ; Aged ; Analysis of Variance ; Female ; Humans ; Male ; Middle Aged ; Risk Factors |
| Abstract: | Acetylcholine test is widely used for the investigation of endothelium function. Acetylcholine induces paradoxical vasoconstriction, if endothelium of coronary artery is damaged. The aim of this study was to investigate the endothelium dysfunction among the patients who have complaints of the chest pain and at the same time no significant changes are found in their coronary arteries by angiography. The impact of the risk factors (smoking, hypertension, positive family history, and hypercholesterolemia) to the lack of endothelium function was studied as well. Intracoronary acetylcholine test was performed for 100 patients (52 males and 48 females). Acetylcholine was given in two steps (10(-6) mol/l and 3.3x10(-6) mol/l) followed by the 300 microg of nitroglycerin. The change of the diameter in comparison with baseline was assessed in left anterior descending and left circumflex arteries. Vasoconstriction of more than 5% from baseline was interpreted as endothelium dysfunction. Coronary vessels from 8 patients reacted to the acetylcholine infusion by vasodilatation and in 92 patients paradoxical vasoconstriction of more than 5% was induced. However, such risk factors as smoking, hypertension, positive family history, and acute coronary syndrome in the past had negative impact to the endothelium dysfunction (p |
| Substance Nomenclature: | 0 (Vasodilator Agents); N9YNS0M02X (Acetylcholine) |
| Entry Date(s): | Date Created: 20040414 Date Completed: 20060209 Latest Revision: 20180614 |
| Update Code: | 20260130 |
| PMID: | 15079112 |
| Database: | MEDLINE |
Comparative Study; English Abstract; Journal Article