| Title: |
Comparative study of selected Rosa varieties’ metabolites through UPLC-ESI-MS/MS, chemometrics and investigation of their insecticidal activity against Culex pipiens L. |
| Alternate Title: |
دراسة مقارنة بين نواتج الأيض لأنواع مختاره من روزا من خلال تحليل الكتلة عالي الكفاءة والكيموميترى وتقييم نشاطهم كمبيدات حشريه ضد كيولكس بيبيينز. (Arabic) |
| Authors: |
Elhawary, Esraa A.; Mostafa, Nada M.; Shehata, Ahmed ZI.; Labib, Rola M.; Singab, Abdel Nasser B. |
| Source: |
Jordan Journal of Pharmaceutical Sciences; Dec2021, Vol. 14 Issue 4, p417-433, 17p |
| Subject Terms: |
Culex pipiens; Insecticides; Flavonoid glycosides; Principal components analysis; Pyrethroids; Chemometrics; Metabolites; Plant phenols |
| Abstract (English): |
The 70 % methanolic extracts of three Rosa varieties (aerial parts & flowers); Rosa banksiae var. banksiae Ait. (RBW); Rosa polyantha Thunb. 'orange fairy' (RPO) and Rosa polyantha Thunb. 'white fairy' (RPW) were quantified using UPLC-ESI-MS/MS. Sixty one compounds were identified where flavonoid glycosides were the most abundant. Principal component analysis (PCA) and Hierarchical cluster analysis (HCA) discriminated the six samples into four clusters where RBW-F & RPW-A formed one cluster, RPW-F & RPO-F formed another and RPO-A and RBW-A were in two separate clusters. The six Rosa extracts were tested as insecticidal agents against Culex pipiens L. larvae and pupae and their fecundity reducing activity was evaluated for the emerging adult mosquitoes. RPW flowers and aerial parts’ extracts demonstrated powerful larvicidal and pupicidal activities with LC50 373.3 and 383.2 ppm, respectively. Sterility indices reached 51.4% at highest concentrations used. All flower extracts possessed significantly high mortality and sterility activities (P < 0.001) compared to the aerial parts (P < 0.01).The UPLC-MS/MS metabolic profile of the extracts showed their richness in polyphenolic compounds. The 70% methanolic extracts of RBW, RPO and RPW aerial parts and flowers can be utilized as natural and safe plantbased insecticides for C. pipiens (filariasis vector) control. [ABSTRACT FROM AUTHOR] |
| Abstract (Arabic): |
باستخدام تحليل الكتلة عالي الكفاءة تم القياس الكمي لمستخلصات الميثانول بتركيز 70 % لثلاث تنوعات من ا روز (الأجزاء الهوائية والورود) وهم ا روز بانكزيا تنوع بانكزيا، ا روز بوليانسا "الورد البرتقالى" و ا روز بوليانسا "الورد الأبيض" وتم التعرف وتحديد نسبه 61 مركب أغلبهم من جلايكوسيدات الفلافونويد. تم تقسيم العينات الست إلى أربعه أقسام باستخدام تحليل المكون وقد (RBW-F & RPW-A), (RPW-F & RPO-F), RPO-A and RBW-A وهم الهرمى المكون وتحليل الأساسي تم قياس نشاط الست عينات كمبيدات حشريه ضد كيولكس بيبيينز ا طور اليرقات والشرانق وكذلك قدرتهم على تقليل الخصوبة للحشرات البالغة. تمكنت مستخلصات الأجزاء الهوائية والورود ل RPW من قتل اليرقات والشرانق بأعلى كفاءه LC50 ppm 2.383 and 3.373 لكل منهما تباعا ووصل مؤشر العقم إلى 4.51 %عند أعلى تركيز مستخدم كذلك كانت مستخلصات الورود أقوى من مستخلصات الأجزاء الهوائية. ومما سبق يمكن أن نستخدم مستخلصات and RPO, RBW RPW كمبيدات حشرية من أصل نباتي آمنه وفعاله ضد ناقل داء الفيل الكيولكس بيبيينز. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |