| Title: |
European recommendations for management of immune checkpoint inhibitors‐derived dermatologic adverse events. The EADV task force 'Dermatology for cancer patients' position statement. |
| Authors: |
Apalla, Z.; Nikolaou, V.; Fattore, D.; Fabbrocini, G.; Freites‐Martinez, A.; Sollena, P.; Lacouture, M.; Kraehenbuehl, L.; Stratigos, A.; Peris, K.; Lazaridou, E.; Richert, B.; Vigarios, E.; Riganti, J.; Baroudjian, B.; Filoni, A.; Dodiuk‐Gad, R.; Lebbé, C.; Sibaud, V. |
| Source: |
Journal of the European Academy of Dermatology & Venereology; Mar2022, Vol. 36 Issue 3, p332-350, 19p |
| Subject Terms: |
IMMUNE checkpoint proteins; TASK forces; DRUG side effects; CANCER patients; IMMUNE checkpoint inhibitors |
| Abstract: |
The introduction of immune checkpoint inhibitors (ICIs) opened a new era in oncologic therapy. The favourable profile of ICIs in terms of efficacy and safety can be overshadowed by the development of immune‐related adverse events (irAEs). Dermatologic irAEs (dirAEs) appear in about 40% of patients undergoing immunotherapy and mainly include maculopapular, psoriasiform, lichenoid and eczematous rashes, auto‐immune bullous disorders, pigmentary disorders, pruritus, oral mucosal lesions, hair and nail changes, as well as a few rare and potentially life‐threatening toxicities. The EADV task force Dermatology for Cancer Patients merged the clinical experience of the so‐far published data, incorporated the quantitative and qualitative characteristics of each specific dirAEs, and released dermatology‐derived, phenotype‐specific treatment recommendations for cutaneous toxicities (including levels of evidence and grades of recommendation). The basic principle of management is that the interventions should be tailored to serve the equilibrium between patients' relief from the symptoms and signs of skin toxicity and the preservation of an unimpeded oncologic treatment. [ABSTRACT FROM AUTHOR] |
| : |
Copyright of Journal of the European Academy of Dermatology & Venereology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Complementary Index |