| Title: |
Nivolumab and interferon-γ rescue therapy to control mixed mould and bacterial superinfection after necrotizing fasciitis and septic shock. |
| Authors: |
Lukaszewicz, Anne-Claire1,2 (AUTHOR) anne-claire.lukaszewicz@chu-lyon.fr; Venet, Fabienne2,3,4 (AUTHOR); Boibieux, André5 (AUTHOR); Lherm, Mathilde6,7 (AUTHOR); Devigne, Bertrand1 (AUTHOR); Monneret, Guillaume2,3 (AUTHOR) |
| Source: |
Medical Mycology Case Reports. Sep2022, Vol. 37, p19-22. 4p. |
| Abstract: |
Immunosuppression is a major feature of septic shock and patients are at increased risk for opportunistic infections. We describe a successful use of immunostimulation to treat mixed mould and bacterial superinfection in a previously healthy 38-year-old female patient admitted for severe extensive fasciitis. Interferon gamma associated with nivolumab reversed successfully deactivation of immune cells assessed by altered expressions of monocyte human leukocyte antigen-DR (HLA-DR) and lymphocyte programmed death receptor-1 (PD-1). Immunosuppressed patients in ICU with invasive bacterial and fungal infections may benefit from immunostimulation. [ABSTRACT FROM AUTHOR] |
| Database: |
Supplemental Index |