| Title: |
Impact of Weight Loss on the Severity of Albuminuria in Obese Diabetic Patients Undergoing Laparoscopic Sleeve Gastrectomy and One-Anastomosis Gastric Bypass. |
| Authors: |
Salman, Ahmed Abdallah; Salman, Mohamed Abdalla; Aon, Mohamed H; Mahdy, Reem Ezzat; Abdallah, Ahmed; Shemy, Gamal Galal; Hassan, Ahmed M; Amin, Fatema Alzahraa Samy; Labib, Safa |
| Source: |
International Journal of General Medicine; Aug2022, Vol. 15, p6405-6413, 9p |
| Subject Terms: |
GASTRIC bypass; GASTRIC banding; SLEEVE gastrectomy; WEIGHT loss; PEOPLE with diabetes; BARIATRIC surgery; TYPE 2 diabetes |
| Abstract: |
Aim: To examine the effect of weight-loss induced bariatric procedures on albuminuria levels among diabetic patients suffering from obesity. Methods: Adults patients who suffer from morbid obesity and type 2 diabetes mellitus (T2DM) were included in a prospective cohort study. Subjects were scheduled to undergo laparoscopic sleeve gastrectomy (LSG) or one-anastomosis gastric bypass (OAGB). The albumin-to-creatinine ratio (ACR) was adopted to assess the degree of albuminuria. Microalbuminuria was determined as a ratio of > 2.5– 30 mg/mmol and > 3.5– 30 mg/mmol for males and females, respectively, while macroalbuminuria was diagnosed when the ACR exceeded > 30 mg/mmol. Results: The mean uACR decreased significantly from 20.95± 16.89 to 9.92± 12.69mg/mmol in LSG cohort (p < 0.001), and from 19.52± 16.65 to 9.34± 11.77mg/mmol in the OAGB cohort, with no statistically considerable differences between both cohorts at the end of follow-up (p = 0.78). Twelve months after the procedures, the percentages of cases with microalbuminuria decreased significantly to 23.8% and 23.9%, respectively (p < 0.001); likewise, the percentages of cases with macroalbuminuria significantly decreased to 7.9% and 7.5% in the LSG and OAGB groups, respectively (p < 0.001). There were no statistically considerable differences between LSG and OAGB regarding the percentages of patients with micro or macroalbuminuria at the end of follow-up. Besides, there were no significant associations between the degree of weight loss and improvement (p = 0.959) or remission (p = 0.73) of microalbuminuria. Conclusion: Bariatric surgery significantly reduced the severity of albuminuria 1-year after the procedure, with no preference for one procedure over the other. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |