Level of nitric oxide in hypertensive patients scheduled on general anaesthesia.
| Title: | Level of nitric oxide in hypertensive patients scheduled on general anaesthesia. |
|---|---|
| Authors: | Shirgoska B; Clinic for Ear, Nose and Throat Surgery, Clinical Centre, Skopje, R. Macedonia.; Trajkovska T; Soljakova M; Simjanovska L; Isijanovska R; Netkovski J; Efremov GD |
| Source: | Prilozi [Prilozi] 2005 Aug; Vol. 26 (1), pp. 13-24. |
| Publication Type: | Journal Article; Randomized Controlled Trial |
| Language: | English |
| Journal Info: | Publisher: De Gruyter Country of Publication: Germany NLM ID: 101189513 Publication Model: Print Cited Medium: Print ISSN: 0351-3254 (Print) Linking ISSN: 03513254 NLM ISO Abbreviation: Prilozi Subsets: MEDLINE |
| Imprint Name(s): | Publication: : Berlin : De Gruyter; Original Publication: Skopje : Makedonska akademija na naukite i umetnostite, Oddelenie za biološki i medicinski nauki, 1980- |
| MeSH Terms: | Anesthesia, General*; Hypertension/*blood ; Nitric Oxide/*blood; Ear, Middle/surgery ; Hypertension/physiopathology ; Adult ; Anesthetics, Inhalation ; Blood Pressure ; Female ; Humans ; Male ; Middle Aged ; Nitrous Oxide ; Oximetry ; Vascular Resistance |
| Abstract: | In this prospective study we have analysed the level of nitric oxide in hypertensive patients scheduled for general anaesthesia. In the study were included thirty-four patients with chronicle inflammatory disease of the middle ear who have undergone surgical treatment at the Clinic for Ear, Nose and Throat Surgery. The aim of our study was to determine the plasma level of nitric oxide (NO) and its effects on the circulatory system in hypertensive patients during the general anaesthesia maintained with inhalation of oxygen and nitrous oxide (O2/N2O) mixture. Patients were divided in two groups. During the maintenance of general anaesthesia the patients from the first group were ventilated with O2/N2O, while patients from the second group were ventilated with oxygen and air (O2/air) mixture. The other principles during the general anaesthesia were equal for both groups. For determination of the NO plasma levels we have used the enzymatic method according to Conrad et al., 1993. Our results showed that there is a statistically significant difference of NO plasma level between the two groups. The level of NO was higher in the first group (ventilated with O2/N2O) compared to the second group (ventilated with O/air). The mean arterial pressure and systemic vascular resistance were significantly decreased in the first group, as well. Our results suggest that nitrous oxide (N2O) most probably plays the role of NO donor in hypertensive patients during the maintenance of the general anaesthesia with N2O/O2 mixture. |
| Substance Nomenclature: | 0 (Anesthetics, Inhalation); 31C4KY9ESH (Nitric Oxide); K50XQU1029 (Nitrous Oxide) |
| Entry Date(s): | Date Created: 20050825 Date Completed: 20070327 Latest Revision: 20161021 |
| Update Code: | 20260130 |
| PMID: | 16118611 |
| Database: | MEDLINE |
Journal Article; Randomized Controlled Trial