| Title: |
Amino Acid-Based Beverage Interventions Ameliorate Exercise-Induced Gastrointestinal Syndrome in Response to Exertional-Heat Stress: The Heat Exertion Amino Acid Technology (HEAAT) Study. |
| Authors: |
Costa, Ricardo J.S.; Henningsen, Kayla; Gaskell, Stephanie K.; Alcock, Rebekah; Mika, Alice; Rauch, Christopher; Cheuvront, Samuel N.; Blazy, Phil; Kenefick, Robert |
| Source: |
International Journal of Sport Nutrition & Exercise Metabolism; Jul2023, Vol. 33 Issue 4, p230-242, 13p, 3 Charts, 5 Graphs |
| Subject Terms: |
Inflammation prevention; Therapeutic use of amino acids; Blood testing; Gastrointestinal disease prevention; Biomarkers; Proteins; Beverages; Heat exhaustion; Endotoxins; Running; Gastrointestinal diseases; Epithelium; Exercise; Intestines; Fatty acids; Symptoms |
| Abstract: |
The study aimed to determine the effects of two differing amino acid beverage interventions on biomarkers of intestinal epithelial integrity and systemic inflammation in response to an exertional-heat stress challenge. One week after the initial assessment, participants (n = 20) were randomly allocated to complete two exertional-heat stress trials, with at least 1 week washout. Trials included a water control trial (CON), and one of two possible amino acid beverage intervention trials (VS001 or VS006). On VS001 (4.5 g/L) and VS006 (6.4 g/L), participants were asked to consume two 237-ml prefabricated doses daily for 7 days before the exertional-heat stress, and one 237-ml dose immediately before, and every 20 min during 2-hr running at 60% maximal oxygen uptake in 35 °C ambient conditions. A water volume equivalent was provided on CON. Whole blood samples were collected pre-, immediately post-, 1 and 2 hr postexercise, and analyzed for plasma concentrations of cortisol, intestinal fatty acid protein, soluble CD14, and immunoglobulin M (IgM) by ELISA, and systemic inflammatory cytokines by multiplex. Preexercise resting biomarker concentrations for all variables did not significantly differ between trials (p >.05). A lower response magnitude for intestinal fatty acid protein (mean [95% CI]: 249 [60, 437] pg/ml, 900 [464, 1,336] pg/ml), soluble CD14 (−93 [−458, 272] ng/ml, 12 [−174, 197] ng/ml), and IgM (−6.5 [−23.0, 9.9] MMU/ml, −10.4 [−16.2, 4.7] MMU/ml) were observed on VS001 and V006 compared with CON (p |
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| Database: |
Complementary Index |