[A boy with Churg-Strauss syndrome and thrombosis associated with eosinophilia].
| Title: | [A boy with Churg-Strauss syndrome and thrombosis associated with eosinophilia]. |
|---|---|
| Transliterated Title: | Een jongen met churg-strauss-syndroom en trombose samenhangend met eosinofilie. |
| Authors: | van Ledden-Klok MJ; Universitair Medisch Centrum St Radboud, afd. Kindergeneeskunde, Postbus 9101, 65oo HB Nijmegen.; Fiselier TJ; Draaisma JM |
| Source: | Nederlands tijdschrift voor geneeskunde [Ned Tijdschr Geneeskd] 2006 Apr 22; Vol. 150 (16), pp. 913-7. |
| Publication Type: | Case Reports; English Abstract; Journal Article |
| Language: | Dutch; Flemish |
| Journal Info: | Publisher: Vereniging NTvG Country of Publication: Netherlands NLM ID: 0400770 Publication Model: Print Cited Medium: Print ISSN: 0028-2162 (Print) Linking ISSN: 00282162 NLM ISO Abbreviation: Ned Tijdschr Geneeskd Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2017?-: Amsterdam : Vereniging NTvG; Original Publication: Houten : Bohn Stafleu van Loghum |
| MeSH Terms: | Churg-Strauss Syndrome/*complications ; Eosinophilia/*complications ; Thrombosis/*complications; Anticoagulants/therapeutic use ; Churg-Strauss Syndrome/diagnosis ; Eosinophilia/diagnosis ; Thrombosis/diagnosis ; Thrombosis/drug therapy ; Thrombosis/surgery ; Adolescent ; Echocardiography ; Humans ; Male |
| Abstract: | A 13-year-old boy, recently diagnosed as having Churg-Strauss syndrome, presented with a thrombus at the level of the aortic bifurcation. Echocardiography revealed a left-ventricular thrombus as well. He was treated by means of surgical thrombectomy, corticosteroids, heparinisation and a coumarine derivative. Eosinophilia (an increase in the number of eosinophilic granulocytes in the circulation or tissues) occurs in various diseases, such as allergic diseases, parasitic infestations, haematologic diseases and autoimmune diseases like the rare Churg-Strauss syndrome. It appears likely that eosinophilia played an important role in the development of both thrombi in the described patient. Eosinophils produce cationic proteins that may inhibit the effect of natural anticoagulants. Infiltration of eosinophils may also cause endocardial damage with the subsequent formation of intracardial thrombi. |
| Substance Nomenclature: | 0 (Anticoagulants) |
| Entry Date(s): | Date Created: 20060512 Date Completed: 20060703 Latest Revision: 20061115 |
| Update Code: | 20260130 |
| PMID: | 16686093 |
| Database: | MEDLINE |
Case Reports; English Abstract; Journal Article