Analysis of the factors related to mortality in patients with bronchiectasis.
| Title: | Analysis of the factors related to mortality in patients with bronchiectasis. |
|---|---|
| Authors: | Onen ZP; Department of Pulmonary Diseases, School of Medicine, Ankara University, Ankara, Turkey. zponen@yahoo.com; Gulbay BE; Sen E; Yildiz OA; Saryal S; Acican T; Karabiyikoglu G |
| Source: | Respiratory medicine [Respir Med] 2007 Jul; Vol. 101 (7), pp. 1390-7. Date of Electronic Publication: 2007 Mar 19. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Elsevier Country of Publication: England NLM ID: 8908438 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0954-6111 (Print) Linking ISSN: 09546111 NLM ISO Abbreviation: Respir Med Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2003- : Oxford : Elsevier; Original Publication: London : Baillière Tindall, in association with the British Thoracic Society, [c1989- |
| MeSH Terms: | Bronchiectasis/*mortality; Bronchiectasis/complications ; Bronchiectasis/physiopathology ; Carbon Dioxide/blood ; Hypercapnia/etiology ; Hypoxia/etiology ; Oxygen/blood ; Turkey/epidemiology ; Vaccination/statistics & numerical data ; Age Factors ; Aged ; Aged, 80 and over ; Epidemiologic Methods ; Female ; Humans ; Male ; Middle Aged ; Partial Pressure ; Prognosis ; Respiratory Mechanics |
| Abstract: | Background: Bronchiectasis is a common disabling but rarely fatal disease. However the long-term prognosis and risk factors for mortality are not well known.; Objective: The aim of this study was to determine prospectively the survival and predictive factors of mortality in patients with bronchiectasis, during 4-year follow-up.; Patients and Methods: From September 2000 to January 2005 survival of bronchiectasis (as evaluated by computed tomography) and predictors of mortality were assessed in 98 outpatients. Fifty-one of the patients had self-reported history of pulmonary infection including tuberculosis. Baseline data, reevaluated in every single year according to scheduled visits.; Results: The mean age was 61+/-10 and 74% of the patients were female. In total, 16 patients (16.3%) died; mean survival time was 44.06+/-1.6 months. The survival rates were 97%, 89%, 76%, 58% at 1, 2, 3 and 4 years, respectively. Cox proportional hazard model revealed that long-term mortality was significantly associated with age, body mass index (BMI), Medical Research Council (MRC) dyspnea scale, vaccination, radiographic extent, hypoxemia, hypercapnia and functional parameters. However, MRC and BMI had more significant effects on the mortality than the functional parameters.; Conclusions: These results suggest that high BMI, regular vaccination and scheduled visits may have beneficial effects on the survival of bronchiectasis. Besides, presence of hypoxemia, hypercapnia, dyspnea level and radiographic extent were more closely correlated with mortality. |
| Substance Nomenclature: | 142M471B3J (Carbon Dioxide); S88TT14065 (Oxygen) |
| Entry Date(s): | Date Created: 20070322 Date Completed: 20070911 Latest Revision: 20260128 |
| Update Code: | 20260130 |
| DOI: | 10.1016/j.rmed.2007.02.002 |
| PMID: | 17374480 |
| Database: | MEDLINE |
Journal Article