[The effect of cimetidine and gastrozepin on liver function and the pharmacotherapy of "hepatogenous" gastroduodenal ulcers and erosions].
| Title: | [The effect of cimetidine and gastrozepin on liver function and the pharmacotherapy of "hepatogenous" gastroduodenal ulcers and erosions]. |
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| Transliterated Title: | Vliianie tsimetidina i gastrotsepina na sostoianie pecheni i farmakoterapiia "gepatogennykh" gastroduodenal'nykh iazv i éroziĭ. |
| Authors: | Geller LI; Bessonova GA; Griaznova MV |
| Source: | Terapevticheskii arkhiv [Ter Arkh] 1991; Vol. 63 (8), pp. 78-81. |
| Publication Type: | Case Reports; Comparative Study; Journal Article |
| Language: | Russian |
| Journal Info: | Publisher: ZAO 'Konsilium Medikum Country of Publication: Russia (Federation) NLM ID: 2984818R Publication Model: Print Cited Medium: Print ISSN: 0040-3660 (Print) Linking ISSN: 00403660 NLM ISO Abbreviation: Ter Arkh Subsets: MEDLINE |
| Imprint Name(s): | Publication: : Moskva : ZAO 'Konsilium Medikum'; Original Publication: Moskva : Izdatelʹstvo Medit︠s︡ina |
| MeSH Terms: | Cimetidine/*adverse effects ; Liver/*drug effects ; Peptic Ulcer/*drug therapy ; Pirenzepine/*adverse effects; Anti-Ulcer Agents/therapeutic use ; Chemical and Drug Induced Liver Injury/etiology ; Cimetidine/administration & dosage ; Liver/physiopathology ; Liver Cirrhosis/complications ; Peptic Ulcer/etiology ; Peptic Ulcer/physiopathology ; Pirenzepine/administration & dosage ; Adult ; Drug Evaluation ; Drug Therapy, Combination ; Humans ; Male ; Middle Aged ; Time Factors |
| Abstract: | Toxic hepatitis developed but in one out of 127 peptic ulcer patients treated with cimetidine. In patients (n-142) treated with gastrozepine, no cases of toxic hepatitis were recorded. These anti-ulcer agents did not influence absorptive capacities of the liver or hepatic blood flow. Meanwhile microsomal exidase (antitoxic) function of hepatocytes noticeably declined as a result of cimetidine treatment in every 8th patient with peptic ulcer subjected to the continuous 5-week treatment with the drug and in every 5th patient given the treatment (maintenance included) for a longer time. In patients suffering from liver cirrhosis with secondary gastroduodenal ulcers or multiple erosions, the 5-week treatment either with almagel and platyphylline or gastrozepine provided approximately similar results and promoted ulcer and erosion healing in half the cases. Adjuvant 3-week therapy with sucralfate (venter) having cytoprotective properties led to the disappearance of gastroduodenal ulcers and erosions in 23 out of 26 patients, in whom the previous treatment was ineffective. |
| Substance Nomenclature: | 0 (Anti-Ulcer Agents); 3G0285N20N (Pirenzepine); 80061L1WGD (Cimetidine) |
| Entry Date(s): | Date Created: 19910101 Date Completed: 19920330 Latest Revision: 20161123 |
| Update Code: | 20260130 |
| PMID: | 1792625 |
| Database: | MEDLINE |
Case Reports; Comparative Study; Journal Article