| Title: |
Theme 4 In Vivo Experimental Models. |
| Authors: |
Vandenakker, A.; Bird, S.; Curzio, D. D.; Benoit, I.; Meek, B.; Gurm, M.; Enno, T.; Civetta, A.; Douville, R.; Forstmeier, P.; Zarnescu, D.; Harji, Z.; Rodriguez, E. C.; Armstrong, G. A. B.; Grybas, V.; Part, C.; Suk, T.; Caballero-Gomez, A.; Heer, M.; Callaghan, S. |
| Source: |
Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration; 2024 Suppl 1, Vol. 25, p136-157, 22p |
| Subject Terms: |
Nuclear matrix; Gene expression; Glial fibrillary acidic protein; Amyotrophic lateral sclerosis; Neural circuitry; Frontotemporal lobar degeneration |
| Abstract: |
The article provides an overview of studies and experiments on Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Degeneration, focusing on topics such as endogenous retrovirus-K (ERVK), alternative polyadenylation, TARDBP mutations, TDP-43 proteinopathy, and RNA aptamers in ALS neuropathology. It also discusses the impact of miRNAs, SOD1 aggregates, and different mechanisms of ALS spread, as well as the potential of direct neuronal reprogramming for ALS therapy. The research utilizes animal models like mice, zebrafish, and C. elegans to investigate the therapeutic potential of compounds and probiotics, aiming to understand disease progression and evaluate novel treatments for ALS. Clinical trials are proposed to assess probiotic supplementation effects on ALS patients. [Extracted from the article] |
| : |
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| Database: |
Complementary Index |