| Title: |
Alcohol Rehabilitation Within 3 Months After Alcohol Hepatitis and Survival: A National Analysis. |
| Authors: |
Parlati, Lucia1,2 (AUTHOR); Mouliade, Charlotte1,2 (AUTHOR); Nguyen Khac, Eric3,4 (AUTHOR); Collier, Mathis5 (AUTHOR); Tzedakis, Stylianos2,6 (AUTHOR); Bouam, Samir7 (AUTHOR); Courtois, Anoisia1 (AUTHOR); Corouge, Marion4 (AUTHOR); Louvet, Alexandre8 (AUTHOR); Pol, Stanislas1,2 (AUTHOR); Sogni, Philippe1,2 (AUTHOR); Benyamina, Amine9,10 (AUTHOR); Rehm, Jürgen11,12,13,14,15,16,17 (AUTHOR); Mathurin, Philippe8 (AUTHOR); Mallet, Vincent1,2 (AUTHOR) vincent.mallet@aphp.fr |
| Source: |
Clinical Gastroenterology & Hepatology. Apr2025, Vol. 23 Issue 5, p808-881. 74p. |
| Abstract: |
There is limited understanding of the benefits of alcohol rehabilitation after alcohol hepatitis (AH). We conducted a 2012 to 2021 national longitudinal study involving adult inpatients diagnosed with AH in France. We assessed the primary outcome of liver transplantation or death within 1 year after AH, including in its complicated form (CAH) defined as ≥2 hepatic or extrahepatic complications within 4 weeks after AH. The primary exposure was in-hospital alcohol rehabilitation within 3 months following AH. Patients who died (6.5%; n = 5282) or were censored (12.5%; n = 10,180) ≤4 weeks after AH were excluded. We measured adjusted hazard ratios (aHRs) and adjusted odds ratios (aORs) within the full cohort and propensity-matched samples. Among 65,737 patients (median age, 52 years; interquartile range [IQR], 44–60 years; 76% male), 12% died or underwent liver transplantation. In-hospital alcohol rehabilitation was noted for 25% of patients (15.2% among patients with CAH) and was the primary discharge diagnosis for 13.3%. The 1-year transplant-free survival rates were 94% (95% confidence interval [CI], 94%–95%) for rehabilitated patients, compared with 85% (95% CI, 85%–86%) for those without (aHR, 0.62; 95% CI, 0.57–0.69; P |
| Database: |
Supplemental Index |