| Title: |
Histopathological Changes as a Predictor of Fatal Outcome in Patients With Drug‐Induced Liver Injury. |
| Authors: |
Weber, Sabine; Erhardt, Franziska; Neumann, Jens; Allgeier, Julian; Saka, Didem; Donga, Nirali; Mircheva, Izabel; Balakumar, Rochell; Lange, Christian M.; Gerbes, Alexander L. |
| Source: |
Liver International; Jul2025, Vol. 45 Issue 7, p1-4, 4p |
| Subject Terms: |
STATISTICAL significance; LOGISTIC regression analysis; PROGNOSIS; LIVER biopsy; ASPARTATE aminotransferase |
| Abstract: |
The article focuses on the role of liver biopsy in diagnosing and managing drug-induced liver injury (DILI), emphasizing its prognostic value in identifying patients at risk for liver transplantation (LT) or death. A study involving 136 DILI patients revealed that histopathological features, particularly severe necrosis and ductular proliferation, were significantly associated with fatal outcomes. The authors developed a predictive model combining these histological features with laboratory parameters, achieving high accuracy in forecasting fatal outcomes. The findings underscore the importance of liver biopsy in assessing liver injury severity and guiding treatment decisions, while also noting the need for caution due to potential complications associated with the procedure. [Extracted from the article] |
| : |
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| Database: |
Complementary Index |