Low sociability is associated with reduced size of the corpus callosum in the BALB/cJ inbred mouse strain.
| Title: | Low sociability is associated with reduced size of the corpus callosum in the BALB/cJ inbred mouse strain. |
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| Authors: | Fairless AH; Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Translational Research Laboratory, 125 South 31st Street, Room 2220, Philadelphia, PA 19104-3403, USA.; Dow HC; Toledo MM; Malkus KA; Edelmann M; Li H; Talbot K; Arnold SE; Abel T; Brodkin ES |
| Source: | Brain research [Brain Res] 2008 Sep 16; Vol. 1230, pp. 211-7. Date of Electronic Publication: 2008 Jul 15. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 0045503 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0006-8993 (Print) Linking ISSN: 00068993 NLM ISO Abbreviation: Brain Res Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Amsterdam Elsevier/North-Holland Biomedical Press. |
| MeSH Terms: | Social Behavior*; Corpus Callosum/*physiology; Choice Behavior/physiology ; Organ Size/physiology ; Animals ; Data Interpretation, Statistical ; Female ; Immunohistochemistry ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Orchiectomy ; Ovariectomy ; Species Specificity |
| Abstract: | The behavioral manifestations of autism, including reduced sociability (reduced tendency to seek social interaction), may be related to underdevelopment of the corpus callosum (CC). The BALB/cJ inbred mouse strain is a useful model system for testing the relationship between reduced sociability and CC underdevelopment. BALB/cJ mice show low levels of sociability, on average, but substantial intrastrain variability in sociability, as well as striking variability in CC development. This study tested the hypothesis that sociability is positively correlated with CC size within the BALB/cJ inbred strain. 30-day-old BALB/cJ and C57BL/6J mice were tested for sociability towards gonadectomized A/J stimulus mice in a social choice task. The size of the corpus callosum was measured histologically at the midsagittal plane. BALB/cJ mice showed a significant positive correlation between the tendency to sniff the stimulus mouse and size of the CC relative to brain weight. C57BL/6J mice showed consistently high levels of sociability and normal corpus callosum development. These results suggest that abnormal white matter structure is associated with deficits in sociability in BALB/cJ mice. Additional studies are warranted to elucidate the relationship between brain connectivity and sociability in this model system. |
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| Grant Information: | R01 MH080718 United States MH NIMH NIH HHS; R01MH080718 United States MH NIMH NIH HHS |
| Entry Date(s): | Date Created: 20080730 Date Completed: 20081205 Latest Revision: 20250529 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC2629607 |
| DOI: | 10.1016/j.brainres.2008.07.025 |
| PMID: | 18662677 |
| Database: | MEDLINE |
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't