| Title: |
Predictor biomarkers for cognitive impairment in Temporal Lobe Epilepsy in adults. |
| Authors: |
Abdelazeem Hassanein, Ibrahim Mohamed; Elmongui, Azza Elmongui; Atta Mashaly, Mervat El-Sayed; Mohammed El-Sayed, Nehal Tharwat; Elgamal, Shimaa Ahmed; Mohammed Mustafa, Wessam Fathi |
| Source: |
Cuestiones de Fisioterapia; 2025, Vol. 54 Issue 2, p2154-2175, 22p |
| Subject Terms: |
TEMPORAL lobe epilepsy; STATISTICAL significance; COGNITION disorders; TEMPORAL lobe; SEIZURES (Medicine) |
| Abstract: |
Background: The most frequent cause for focal seizures is temporal lobe epilepsy (TLE). The temporal lobe is primarily responsible for speech, memory, learning, and affective behavior. The previously mentioned functions would be disrupted if the lobe's internal structures were damaged. Aim: To determine cognitive impairment in TLE in adults and to investigate if there was an association between serum levels of HMGB1 and S100B expressions with cognitive impairment in TLE for the possibility of detecting predictive biomarkers for cognitive impairment in TLE. Subjects and methods: This study was a case control study of 200 subjects at the Neurology Department at Mansoura University and Kafrelsheikh University Hospitals. They were divided into two groups: Group A: 100 patients with TLE and Group B: 100 healthy controls. Results: A statistically significant higher mean MoCA score was discovered among the control than the cases group (28.66±0.794 versus 17.27±7.21, respectively). A statistically significant higher median serum concentration of HMGB1and S100B was discovered among cases compared to the control group (p-value |
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| Database: |
Complementary Index |