| Title: |
Assessing Pathological Complete Response in Locally Advanced Breast Cancer: The Role of Inflammatory and Nutritional Biomarkers. |
| Authors: |
Duran, Eda Nur; Yeniyurt, Elif Kadıoğlu; Aydın, Sabin Göktaş; Erkinüresin, Taşkın; Dağıstanlı, Sevinç; İşbilen, Zeynep Betül Yıldız; Üstüner, Müge; Aydın, Fatma Bengü; Tabak, Ömür |
| Source: |
Acta Haematologica Oncologica Turcica; 2025, Vol. 58 Issue 2, p1-7, 7p |
| Subject Terms: |
Platelet lymphocyte ratio; Metastatic breast cancer; Neutrophil lymphocyte ratio; Receiver operating characteristic curves; Neoadjuvant chemotherapy |
| Abstract: |
Aim Neoadjuvant chemotherapy (NAC) aims to achieve pathological complete response (pCR), which is linked to improved outcomes in locally advanced breast cancer (LABC). Identifying reliable predictors of pCR remains a clinical priority. Methods This retrospective study included 44 women, with a median age of 50 years, with stage 2B-3C breast cancer who underwent NAC followed by surgery. Inflammatory markers [systemic inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), erythrocyte-to-lymphocyte ratio (ELR), lymphocyte-to-C (LCR)] and nutritional indices [glucose-to-albumin ratio (GAR), hemoglobin-to-albumin ratio (HAR), prognostic nutritional index (PNI)] were analyzed. Receiver operating characteristic analysis determined optimal cut-off values, and binary logistic regression evaluated independent predictors of pCR. Results The overall pCR rate was 38.6%. Among histological subtypes, luminal B tumors were more frequent in both groups, with 40.7% in the non-pCR group and 29.4% in the pCR group. Triple-positive and HER2-positive tumors were more common in the pCR group. GAR ≤2.04 emerged as the only independent predictor of pCR (odds ratio=0.09, 95% confidence interval: 0.01-0.70, p=0.02). ELR >2.69 and LCR >0.64 showed significant associations with pCR (p=0.03 and p=0.04, respectively), though they lacked independent predictive value. SII, NLR, PLR, HAR, and PNI demonstrated no significant correlation with pCR. Conclusion This study assessed significant cut-off values, ELR >2.69 and LCR >0.64, that might predict the pCR in LABC. GAR, with a cut-off value of 2.04, was found to be an independent predictive marker for pCR. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |