| Title: |
Effect of Maerua subcordata (Gilg) DeWolf extracts on blood glucose level in rodents. |
| Authors: |
Hiben, Mebrahtom Gebrelibanos1 mebrahtom.gebrelibanos@mu.edu.et; Manasib, Tilahun Arefe2,3; Tekulu, Gebretsadkan Hintsa1,3; Tareke, Helen Bitew1,3; Tsegay, Amanueal Tesfay3,4; Kassegn, Hagos Hailu3,5; Kalayu, Tesfay Haile1,3; Asfaw, Yohannes Tekle2 |
| Source: |
Tanzania Journal of Health Research. 2025 Supplement, Vol. 26, Following p2646-2657. 16p. |
| Abstract: |
Background: Maerua subcordata is used as a herbal medicine for the management of diabetes, among others. This study aimed to evaluate the safety and effects on blood glucose level (BGL) of M. subcordata extracts using a rodent model. Methods: The leaf and root extracts were first evaluated using STZ-induced diabetic Swiss albino mice at doses of 250 and 500 mg/kg body weight. Then the fruit, leaf, root and seed extracts were studied using normoglycemic, glucose-challenged, and STZ-nicotinamide induced diabetic SD rats at a dose of 300 mg/kg body weight. Results: acute toxicity studies at 2g/kg revealed no obvious toxicity signs. Leaf extract exhibited a considerable fasting BGL-lowering effect in normoglycemic, glucose-challenged, and STZ-nicotinamide induced diabetes SD rats and STZ-induced diabetic mice that were comparable to glibenclamide and metformin. The root extract enhanced BGL in normoglycemic and glucose-challenged rats but displayed milder anti-diabetic activity in STZ-nicotinamide induced diabetes rats and appreciable anti-diabetic activity in STZ-induced diabetes mice, with the lower dose showing higher activity. The fruit and seed extracts enhanced glycaemia in normoglycemic but controlled glycaemia in glucose-challenged rats, implying these extracts may control postprandial hyperglycemia. Conclusion: M. subcordata leaf extract revealed significant and dose-dependent glycaemia-lowering effect in different rodent models, while the root extract showed inconsistent antidiabetic activity, both in terms of dose and rodent type. The fruit and seed extracts showed postprandial hyperglycemia-controlling potential. Accordingly, verified, optimized, and standardized botanical preparation may be suggested, expecting potential health benefits, including the management of diabetes. [ABSTRACT FROM AUTHOR] |
| Database: |
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