| Title: |
Neurocognitive outcomes and memory transfer in heart transplantation. |
| Authors: |
Ashinze, Patrick; Salawu, Wuraola; Akande, Eniola; Banerjee, Suvam; Idris-Agbabiaka, Abdullaah; Chukwu, Bethrand; Mafua, Nelson; Ngirigwa, Francis; Okeoyo, Tesleem; Olowookere, Stephen; Adeleye, Victor Mayowa; Olajuwon, Joseph Tolulope; Aboderin, Caleb; Olasemo, Ayodeji; Musa, Lukman Abiodun |
| Source: |
Global Cardiology Science & Practice; 2025, Vol. 2025 Issue 4, p1-28, 28p |
| Subject Terms: |
Heart transplantation; Personality change; Transplantation of organs, tissues, etc.; Knowledge transfer; Epigenetics; Psychological adaptation; Cell communication; Cognitive ability |
| Abstract (English): |
Cardiac transplantation remains a life-saving intervention for end-stage cardiac disease, substantially improving survival and quality of life. While physiological and immunological challenges, such as graft rejection and immunosuppression, are wellcharacterized, emerging evidence underscores complex neurocognitive and psychological transformations in recipients. These include debated phenomena such as shifts in memory, behavior, and personality, which challenge conventional paradigms of transplantation outcomes. Methodology: This scoping review was conducted by performing comprehensive literature searches of databases including PubMed, Scopus, Google Scholar, Cochrane Library, and PsycINFO using MeSH keywords: "heart transplant," "neurocognitive outcomes," "cellular memory," AND "personality transfer." The timeline spanned 1990 through June 2025. Inclusion criteria: (1) peer-reviewed clinical studies; (2) case reports providing detailed narrative descriptions relevant to memory/personality changes; (3) manuscripts written in English; (4) reports including =5 participants/patients. Exclusion criteria: (1) non-transplant cardiac studies; (2) animal research; (3) editorials/opinions/gray literature; (4) non-English manuscripts. Study quality was assessed through manual review of documented accounts alongside corresponding peer-reviewed manuscripts. Results: This review synthesizes theories, case studies, and mechanistic hypotheses from published reports, exploring neurocognitive trajectories and purported memory-behavioral transfer between donors and recipients. Epigenetic modifications--such as DNA methylation and histone remodeling--are hypothesized to alter gene expression in donor-derived cells, potentially influencing recipient cognition and behavior. Concurrently, immune-brain crosstalk, mediated by cytokines and neuroinflammatory pathways, may exacerbate psychological distress, including identity dissonance and anxiety. Cognitive-behavioral interventions and psychosocial support emerge as critical tools for post-transplant adaptation. Conclusion: Current evidence on memory transfer remains inconclusive, yet its implications for biological-psychological interconnectedness warrant rigorous interdisciplinary inquiry. By integrating neuroscientific, immunological, and psychological frameworks, future research can elucidate the mechanisms underlying post-transplant neurocognitive phenomena, optimizing therapeutic strategies and patient counseling. [ABSTRACT FROM AUTHOR] |
| Abstract (Arabic): |
المقال يركز على النتائج العصبية المعرفية وظواهر نقل الذاكرة في زراعة القلب. يبرز أن زراعة القلب تحسن بشكل كبير من البقاء وجودة الحياة، إلا أن المتلقين غالبًا ما يواجهون تغييرات عصبية معرفية ونفسية معقدة، بما في ذلك التحولات المحتملة في الذاكرة والسلوك والشخصية. تستعرض المراجعة الأدبيات الموجودة، مستكشفة النظريات ودراسات الحالة المتعلقة بهذه التغييرات، بما في ذلك الفكرة المثيرة للجدل حول "الذاكرة الخلوية"، التي تقترح أن الذكريات أو الصفات قد تُنقل من المتبرعين إلى المتلقين. يدعو المؤلفون إلى مزيد من البحث بين التخصصات لفهم هذه الظواهر بشكل أفضل وتأثيراتها على رعاية المرضى والإرشاد. [Extracted from the article] |
| : |
Copyright of Global Cardiology Science & Practice is the property of Magdi Yacoub Institute and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Complementary Index |