| Title: |
C-reactive protein and procalcitonin as prognostic factors in cardiac surgery patients exposed to extracorporeal circulation. |
| Alternate Title: |
Proteína C reactiva y procalcitonina como factores pronósticos en pacientes de cirugía cardiaca expuestos a circulación extracorpórea. (Spanish) |
| Authors: |
Altamirano-Ramírez, Yader E.; Valdez-Pastora, Milton; Berrios-Muñiz, Edgar O.; Franco-Ortega, Xóchitl; Ocampo Mazariegos, José H.; Marcial-Rivera, Daniel F.; Solís-Loría, Waldemar A.; Gutierrez-Chavarría, Sindy A.; Herrera-Salgado, Jésser M. |
| Source: |
Revista de Sanidad Militar; oct-dic2025, Vol. 79 Issue 4, p1-21, 21p |
| Subject Terms: |
C-reactive protein; MORTALITY; PROGNOSIS; INTENSIVE care units; ARTIFICIAL blood circulation; SURGICAL complications; CARDIAC surgery; CALCITONIN |
| Abstract (English): |
Introduction: the increase in serum levels of procalcitonin (PCT) and C-reactive protein (CRP) in patients post cardiac surgery are potential markers for predicting postoperative complications. Objective: to analyze the behavior of PCT and CRP as prognostic factors in patients exposed to extracorporeal circulation. Methodological design: prospective cohort study, non-random convenience sample, initially 88 postoperative cardiac surgery patients exposed to extracorporeal circulation who were admitted to the Intensive Care Unit (ICU) of the Military Hospital of Nicaragua from May 2022 to October 2023, in Nicaragua. They were distributed according to their postoperative PCT levels in ≥ 2.95 ng/mL and < 2.95 ng/mL in the control group. Results: a total of 76 patients completed the follow-up, distributed among 24 who elevated this marker and 52 who did not. PCT ≥ 2.95 ng/mL was associated with a higher risk of requiring vasopressor use (RR: 2.08, p < 0.001), inotropic agents (RR: 5.77, p < 0.001), the need for postoperative ventilatory support (RR: 30.3, p < 0.001), longer ICU stay, mediastinal bleeding (RR: 40.2, p = 0.009), prolonged mechanical ventilation (RR: 28.1, p < 0.001), and mortality both in the ICU (RR: 23.3, p = 0.03) and at 30 days (RR: 27.5, p = 0.02). Limitations: the study subjects exhibit heterogeneous characteristics that may interfere with the results. Value: this study tested a relatively accessible morbidity and mortality marker. Conclusion: procalcitonin measured 72 hours postoperatively is a good predictor of clinical evolution and mortality in patients exposed to extracorporeal pump circulation. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): |
Introducción: el aumento de los niveles séricos de procalcitonina (PCT) y proteína C reactiva (PCR) en pacientes posoperados de cirugía cardíaca son marcadores potenciales para predecir complicaciones posoperatorias. Objetivo: analizar el comportamiento de la PCT y PCR como factor pronóstico en pacientes expuestos a circulación extracorpórea. Diseño metodológico: estudio de cohorte prospectivo, muestra no aleatoria por conveniencia, inicialmente 88 pacientes posquirúrgicos de cirugía cardiaca expuestos a circulación extracorpórea que ingresaron a la Unidad de Cuidados Intensivos (UCI) del Hospital Militar de Nicaragua de mayo 2022 a octubre 2023, en Nicaragua. Ellos se distribuyeron según sus niveles de PCT posquirúrgica en ≥ 2.95 ng/mL y < 2.95 ng/ mL en grupo de control. Resultados: completaron el seguimiento 76 pacientes, los que se distribuyeron en 24 quienes elevaron este marcador y 52 pacientes que no. La PCT ≥ 2.95 ng/mL se asoció a mayor riesgo de requerir uso de vasopresores (RR:2.08, p= |
| : |
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| Database: |
Complementary Index |