| Title: |
Sonochemical N -demethylation of dextromethorphan—an energy consumption comparison. |
| Authors: |
Christie, Liah D.; Henneberry, Samantha K.; Mohammed, Tehya C.; Scammells, Peter J.; Singer, Robert D. |
| Source: |
Canadian Journal of Chemistry; 2025, Vol. 103 Issue 12, p874-879, 6p |
| Subject Terms: |
Demethylation; Energy consumption; Solvents; Dextromethorphan; Iron catalysts; Sonochemistry; Sustainable chemistry; Drug synthesis |
| Abstract: |
The N-demethylation of alkaloids is a critical step in the synthesis of useful pharmaceutical agents such as Naltrexone, 1, and Naloxone, 2, used in the battle against drug dependency and opioid use disorder. Efforts to make this process more sustainable have been ongoing for a number of years, using a range of iron (0) catalysts, green solvents, and different energy sources to initiate reaction. The use of a sonochemical, iron catalyzed methodology for the N-demethylation of the model alkaloid compound, dextromethorphan, 4, is described herein. The sonochemical demethylation chemistry is comparable to other methods developed in the Singer and Scammells labs. However, when electrical energy consumption is examined, conventional stirring reveals itself as least demanding while liquid assisted grinding and sonochemical approaches were most demanding. Any future scale up of this chemistry using a touted "green and sustainable approach" should therefore consider all green chemistry parameters and metrics collectively. [ABSTRACT FROM AUTHOR] |
| : |
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| Database: |
Complementary Index |