| Title: |
Antimicrobial Activities of Bitter Kola and Molecular Analysis of Organisms causing Bronchitis isolated from Sputum among Patients attending Ladoke Akintola University Teaching Hospital Ogbomoso. |
| Authors: |
Raheem, L. O.; Adegoke, C. O.; Fabiyi, W. A.; Oyeleke, K. O.; Azeez, M. M.; Folorunso, O. A.; Akinlabi, A. M.; Alade, W. A. |
| Source: |
Sokoto Journal of Medical Laboratory Science (SJMLS); Sep2025, Vol. 10 Issue 3, p337-348, 12p |
| Subject Terms: |
GARCINIA; DRUG resistance in bacteria; PLANT extracts; PATHOGENIC microorganisms; ANTI-infective agents; BRONCHITIS; TRADITIONAL medicine |
| Abstract: |
Antimicrobial agents have played a significant role in decreasing the rate of infectious diseases globally. Microbial resistant strains poses a significant health threat, necessitating the search for alternative therapy. Traditionally, antibiotics are becoming less effective resulting in these natural sources of antimicrobial compound being explored, The main objective of this study was to access the antimicrobial activities of Garcinia kola seed extract against a diverse of clinical isolates. By evaluating the efficacy of Garcinia kola seed extract, this research aim to contribute to the development of natural alternatives to conventional antibiotics. Methods include extracting Garcinia kola seed compound, testing the extract on various pathogens and comparing results to standard antibiotics. Findings show promising antimicrobial antibiotics, suggesting Garcinia kola seed extract as a potential natural remedy for antibiotic resistant bacteria. The study begins by extracting bioactive compounds from Garcinia seeds using standard methods. These compounds are then subjected to testing against a diverse range of clinical isolate, including bacteria and fungi commonly found in infection. Methanolic extraction of the phytochemical, the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) against selected clinical pathogen were determined. The MIC and MBC was found to have 0.125 to 100.5mg/ml minimum inhibitory ranges from 0.5 to 100mg/ml pathogen. The MIC of the methanolic leaf extract of the ethnomedicinal, the antimicrobial efficacy of Garcinia kola seed extract was evaluated using two main methods (agar diffusion and broth microdilution). Analysis of data was carried out using Anova with a p-value of |
| : |
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| Database: |
Complementary Index |