Anti-inflammatory activities of Sieboldogenin from Smilax china Linn.: experimental and computational studies.
| Title: | Anti-inflammatory activities of Sieboldogenin from Smilax china Linn.: experimental and computational studies. |
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| Authors: | Khan I; Department of Pharmacy, University of Peshawar, Peshawar 25120, Pakistan. inam_marwat333@yahoo.com; Nisar M; Ebad F; Nadeem S; Saeed M; Khan H; Samiullah; Khuda F; Karim N; Ahmad Z |
| Source: | Journal of ethnopharmacology [J Ethnopharmacol] 2009 Jan 12; Vol. 121 (1), pp. 175-7. Date of Electronic Publication: 2008 Oct 21. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0378-8741 (Print) Linking ISSN: 03788741 NLM ISO Abbreviation: J Ethnopharmacol Subsets: MEDLINE |
| Imprint Name(s): | Publication: Limerick : Elsevier Sequoia; Original Publication: Lausanne, Elsevier Sequoia. |
| MeSH Terms: | Computer Simulation*; Anti-Inflammatory Agents/*pharmacology ; Heterocyclic Compounds, 4 or More Rings/*pharmacology ; Plant Extracts/*pharmacology ; Smilax/*chemistry ; Spiro Compounds/*pharmacology; Anti-Inflammatory Agents/therapeutic use ; Edema/chemically induced ; Edema/drug therapy ; Heterocyclic Compounds, 4 or More Rings/isolation & purification ; Heterocyclic Compounds, 4 or More Rings/therapeutic use ; Lipoxygenase Inhibitors/pharmacology ; Lipoxygenase Inhibitors/therapeutic use ; Plant Extracts/therapeutic use ; Spiro Compounds/isolation & purification ; Spiro Compounds/therapeutic use ; Animals ; Carrageenan ; Female ; Male ; Models, Molecular ; Molecular Conformation ; Phytotherapy ; Rats ; Rats, Wistar |
| Abstract: | Ethnopharmacological Relevance: Smilax china Linn. is extensively used in traditional Chinese medicine (TCM) as well as in Pakistan for several medicinal purposes including their use in inflammatory disorders.; Aim of the Study: The aims of the current study were to validate and assess the folk use of Smilax china Linn. on pharmacological grounds using the isolated compound at molecular, in vivo and computational levels.; Materials and Methods: Seiboldogenin was isolated from ethyl acetate fraction of the plant crude extract. In vitro lipoxygenase and in vivo carrageenan-induced hind paw oedema models were used in experimental studies while molecular docking technique was used to conduct computational study.; Results: Sieboldogenin showed significant lipoxygenase inhibition (IC50: 38 microM). It also exhibited significant inhibition (p |
| Substance Nomenclature: | 0 (Anti-Inflammatory Agents); 0 (Heterocyclic Compounds, 4 or More Rings); 0 (Lipoxygenase Inhibitors); 0 (Plant Extracts); 0 (Spiro Compounds); 0 (sieboldogenin); 9000-07-1 (Carrageenan) |
| Entry Date(s): | Date Created: 20081115 Date Completed: 20090331 Latest Revision: 20161124 |
| Update Code: | 20260130 |
| DOI: | 10.1016/j.jep.2008.10.009 |
| PMID: | 19007873 |
| Database: | MEDLINE |
Journal Article