| Title: |
Calciphylaxis in the Upper GI Tract in an ESRD Patient: An Atypical Presentation and Review of Literature. |
| Authors: |
D. Shirsat, Pallavi; Sonavane, Kunal; Botana, Leonardo Ramirez; Sachdeva, Bharat; Gurumallesh, Poorani |
| Source: |
Case Reports in Nephrology; 12/11/2025, Vol. 2025, p1-7, 7p |
| Subject Terms: |
CALCIPHYLAXIS; CHRONIC kidney failure; NECROSIS; HEMODIALYSIS; GASTROINTESTINAL system; GASTRIC mucosa; SYMPTOMS; ARTERIAL calcification |
| Abstract: |
Calciphylaxis, also referred to as calcific uremic arteriolopathy (CUA), is a rare and life‐threatening condition characterized by vascular calcification, ischemic tissue injury, and high morbidity and mortality. It is predominantly observed in patients with end‐stage renal disease (ESRD) who are undergoing dialysis and typically presents with painful cutaneous ulcers. We report an exceptional case of gastric mucosal CUA in a dialysis‐dependent ESRD patient, presenting with severe upper gastrointestinal bleeding in the absence of preceding skin lesions. Histopathologic examination of gastric biopsies confirmed vascular calcification consistent with CUA. Despite medical intervention, the patient's course was complicated by poor treatment adherence and subsequent fatal outcome. This case underscores the importance of maintaining high index of suspicion for atypical, visceral presentations of CUA in high‐risk ESRD patients. This case was previously presented as a poster at the National Kidney Foundation 2025 Spring Clinical Meeting. Trial Registration: ClinicalTrials.gov identifier: NCT02278692 [ABSTRACT FROM AUTHOR] |
| : |
Copyright of Case Reports in Nephrology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Complementary Index |