| Title: |
Spectrochemical evidence for the reversal of age-related testicular degeneration by young plasma in senile infertility. |
| Authors: |
Teker, Hikmet Taner; Ceylani, Taha; Şengil, Ahmet Zeki |
| Source: |
Anatolian Current Medical Journal (ACMJ); 2025, Vol. 7 Issue 6, p760-769, 10p |
| Subject Terms: |
Plasma exchange (Therapeutics); Fourier transform infrared spectroscopy; Cellular aging; Protein structure; Molecular structure; Plasma products; Testicular diseases |
| Abstract: |
Aims: Senile infertility in males is primarily associated with testicular degeneration, although its precise etiology remains unclear. In recent years, increasing attention has been directed toward strategies aimed at ameliorating age-related physiological deterioration. The present study investigates the potential restorative effects of heterochronic blood plasma exchange between aged and young Wistar rats on the molecular composition of testicular tissue specifically targeting protein, lipid, carbohydrate, and nucleic acid profiles. Methods: Spectral data were acquired via fourier transform infrared (FTIR) spectroscopy and evaluated through principal component analysis (PCA). Results: Compared to the spectral characteristics of young testicular tissue, aged samples exhibited prominent molecular alterations indicative of structural degeneration, including spectral shoulder formation, band broadening, and frequency shifts—particularly associated with β-sheet-rich protein conformations. Notably, phospholipid and glycolipid-associated bands were present in aged controls and young rats receiving aged plasma, but absent in young controls and aged rats treated with young plasma. Similarly, spectral features related to testicular glycogen, methyl rocking, and nucleic acid phosphate groups were lost in aged tissues but preserved in young and rejuvenated aged samples. These alterations were statistically significant (p |
| : |
Copyright of Anatolian Current Medical Journal (ACMJ) is the property of MediHealth Academy (MHA) and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Complementary Index |