| Title: |
Secondary analysis of data from the HeLiX trial regarding the association between estimated blood loss and post-hepatectomy outcomes: towards the definition of a minimal clinically significant difference. |
| Authors: |
Hallet, Julie; Ribeiro, Tiago; Fong, Zhi V; Perri, Giampaolo; Ghorbani, Poya; Sparrelid, Ernesto; Marchegiani, Giovanni; Karanicolas, Paul J; Lin, Yulia; McCluskey, Stuart A; Tarshis, Jordan; Thorpe, Kevin E; Wei, Alice; Dixon, Elijah; Porter, Geoff; Chaudhury, Prosanto; Nanji, Sulaiman; Ruo, Leyo; Tsang, Melanie E; Skaro, Anton |
| Source: |
British Journal of Surgery; Nov2025, Vol. 112 Issue 11, p1-4, 4p |
| Subject Terms: |
Blood loss estimation; Red blood cell transfusion; Surgical complications; Hepatectomy; Perioperative care; Clinical trials |
| Abstract: |
The article focuses on a secondary analysis of data from the HeLiX trial, investigating the relationship between estimated blood loss (EBL) during hepatectomy and postoperative outcomes, specifically the development of a minimal clinically significant difference (MCSD) for EBL. The study found that higher EBL was associated with increased risks of 30-day red blood cell transfusion (RBCT) and major morbidity, with significant risk increases observed up to certain EBL thresholds (1600-1800 ml). The findings aim to establish standardized benchmarks for EBL in surgical research, enhancing the interpretation of outcomes related to hepatectomy. The results will be presented to experts to develop consensus on clinically meaningful EBL differences. [Extracted from the article] |
| : |
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| Database: |
Complementary Index |