| Title: |
Testicular Toxicity of Cypermethrin, Lambda Cyhalothrin and Deltamethrin- A Comparative Histopathological Study. |
| Authors: |
AHMAD, Syeda Nadia; NOSHEEN, Anam; KANWAL, Naila; KANWAL, Muhammad Ali; INAYAT, Iram; AZAM, Iqra; ISMAIL, Tehmina; YOUNIS, Asma; SULEMAN, Sadia; AHMAD, Khawaja Raees |
| Source: |
Fluoride; Jul-Sep2025, Vol. 58 Issue 18, p1-7, 7p |
| Subject Terms: |
CYPERMETHRIN; DELTAMETHRIN; CYHALOTHRIN; SPERMATOGENESIS; HISTOPATHOLOGY; TESTICULAR diseases; LABORATORY mice |
| Abstract: |
Purpose: The present study was designed to explore the comparative toxicological implications of three halogenated type II pyrethroid insecticides that are cypermethrin, deltamethrin and lambda cyhalothrin on testis of adult Swiss Webster male albino mice (Mus musculus). Methods: The animals (40) of almost similar body weight and age were randomly distributed in four groups (N=10) that are; 1: Control group treated with vehicle that is corn oil for three days, 2: Cypermethrin group treated with 0.6 mg/kg body weight for three days using corn oil as vehicle, 3: Deltamethrin and 4: Lambda cyhalothrin groups treated with respective insecticides as in group no 2 that is cypermethrin group. The testes were recovered on the day seven and processed for wax embedded microtomy and Hematoxylin & Eosin (H & E) staining. Results: The results have shown various testicular pathologies in the three insecticide groups. Cypermethrin had shown only one whirl of spermatogonia and few spermatocytes along the basement membrane, while in deltamethrin group the seminiferous tubular sections were having few spermatogonia and spermatocytes as compared to the control and cypermethrin group. Similarly various significant alterations in micrometry as decreasing seminiferous tubular count per 850 µ2 unit area was observed in all the insecticide groups as compared to the control group. Conclusions: The finding among three insecticides suggests that the fluorinated pyrethroid lambda cyhalothrin was most toxic among the three pyrethroids then the brominated pyrethroid deltamethrin. Lambda cyhalothrin may inflict more deleterious effects on the testicular anatomy as compared to the deltamethrin. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |