| Title: |
129Xe-MRI ventilation and acinar abnormalities highlight the significance of spirometric dysanapsis: findings from the NOVELTY ADPro UK substudy. |
| Authors: |
Smith, Laurie J.; Marshall, Helen; Jakymelen, Demi; Biancardi, Alberto; Collier, Guilhem J.; Chan, Ho-Fung; Hughes, Paul J. C.; Brook, Martin L.; Astley, Josh R.; Munro, Ryan; Rajaram, Smitha; Swift, Andrew J.; Capener, David; Bray, Jody; Ball, Jimmy E.; Rodgers, Oliver; Tahir, Bilal A.; Rao, Madhwesha; Norquay, Graham; Weatherley, Nicholas D. |
| Source: |
Thorax; Dec2025, Vol. 80 Issue 12, p900-917, 18p |
| Subject Terms: |
CHRONIC obstructive pulmonary disease; ASTHMA; LUNG diseases; PULMONARY function tests; COMPUTER-assisted image analysis (Medicine); RESPIRATION; LUNG volume |
| Abstract: |
Rationale Airways dysanapsis is defined by CT or spirometry as a mismatch between the size of the airways and lung volume and is associated with increased risk of developing chronic obstructive pulmonary disease (COPD). Lung disease in participants with dysanapsis and a label of asthma and/or COPD remains poorly understood. Methods In participants with asthma and/or COPD, we used 129Xe-MRI to assess ventilation, acinar dimensions and gas exchange, and pulmonary function tests, and compared people with spirometric dysanapsis (forced expiratory volume in 1s (FEV1)/forced vital capacity (FVC)−1.64 z) to those with normal spirometry (FEV1, FVC and FEV1/FVC>−1.64 z). Results From 165 participants assessed in the NOVELTY (NOVEL observational longiTudinal studY) ADPro (advanced diagnostic profiling) study with a physicianassigned diagnosis of asthma and/or COPD, 43 had spirometric dysanapsis and were age-matched to 43 participants with normal spirometry. Participants with dysanapsis had significantly increased ventilation defects (median difference (md) (95% CI) = 4.0% (1.42% to 5.38%), p |
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| Database: |
Complementary Index |