| Title: |
Association of Maternal Inflammatory Markers and Risk Factors with Adverse Pregnancy Outcomes: A Cross-sectional Study. |
| Authors: |
ANANDA, PUTTAIAH; SOMANNAVAR, MANJUNATH S.; BELLAD, MRUTYUNJAYA B.; CHARANTIMATH, UMESH S.; DEEPTHY, MS; J. S. A., STRINGER; GOUDAR, SHIVAPRASAD S. |
| Source: |
Journal of Clinical & Diagnostic Research; Feb2026, Vol. 20 Issue 2, p1-5, 5p |
| Subject Terms: |
Pregnancy outcomes; Low birth weight; C-reactive protein; Cross-sectional method; Ferritin; Hypertension in women; Maternal immune activation; Premature labor |
| Geographic Terms: |
India |
| Abstract: |
Introduction: Adverse pregnancy outcomes are a common health problem, particularly in resource-poor settings. However; their multifaceted causes are not fully understood. Investigating the association between inflammatory markers throughout pregnancy and adverse birth outcomes may provide insights into potential intervention pathways. Aim: To determine the association between maternal inflammatory markers and risk factors with adverse pregnancy outcomes. Materials and Methods: The present cross-sectional study was conducted at Dr Prabhakar Kore Hospital, Belagavi, Karnataka, India between August 2021 and August 2022. The present study included 714 pregnant women aged between 18-40 years, who presented for delivery at the institution. Maternal blood samples were collected before delivery to measure high-sensitivity-C Reactive Protein (hs-CRP), ferritin, albumin, and Erythrocyte Sedimentation Rate (ESR). Chi-square tests were performed to assess the association between these inflammatory markers and adverse pregnancy outcomes (Preterm Birth (PTB), Low Birth Weight (LBW), and stillbirth). Results: The median age of participants was 24 years (Q1, Q3 : 21, 26). Education level, gestational age, higher Body Mass Index (BMI), and history of hypertension were associated with adverse pregnancy outcomes. Serum ferritin levels were significantly higher in the adverse pregnancy outcomes group (48.0 ng/mL; Q1, Q3 : 26.0, 86.0) compared to the group without adverse outcomes (35.0 ng/mL; Q1, Q3 : 18.0, 62.0). Other inflammatory markers showed no statistically significant associations (p |
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| Database: |
Complementary Index |