| Title: |
Effects of neoadjuvant glucagon-like-peptide 1 receptor agonists on weight loss after bariatric surgery. |
| Authors: |
Benavidez, Maria Charina1 (AUTHOR); Redpath, Sophia1 (AUTHOR); Trautmann, Stephanie1 (AUTHOR); Ceron, Santiago1 (AUTHOR); Schimpke, Scott1 (AUTHOR); Myers, Jonathan1 (AUTHOR); Omotosho, Philip1 (AUTHOR); Torquati, Alfonso1 (AUTHOR); Skertich, Nicholas J.1 (AUTHOR) Nicholas_j_skertich@rush.edu |
| Source: |
Surgery for Obesity & Related Diseases. Jan2026, Vol. 22 Issue 1, p18-23. 6p. |
| Abstract: |
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are increasingly prevalent medications used to treat patients with obesity. While bariatric surgery remains the most successful single intervention, many surgical patients have been on a GLP-1RA. This study aims to determine if the neoadjuvant use of GLP-1RA affects surgical weight loss. University Hospital, United States. This retrospective cohort study compared outcomes of patients undergoing sleeve gastrectomy (SG) or Roux-en-Y gastric bypass (RYGB) who were treated preoperatively with and without GLP-1RAs from July 2022 to June 2023. T-tests and multivariable analyses were utilized to determine significant differences in weight loss. Of 422 patients, 36 (8.5%) received neoadjuvant GLP-1RAs and 386 (91.5%) did not. Mean preoperative body mass index (BMI) was 47 for both groups. Median time for GLP1-RAs was 12 months prior to bariatric surgery but not resumed after. There was a significant difference between patients who received neoadjuvant GLP1-RAs versus those who did not at 2 weeks (mean change in BMI of −4.9 vs −3.8, P =.006), but not at 3- (−9 vs −8.4, P =.25), 6- (−12.4 vs −11.2, P =.13), or 12 months (−14.2 [n = 21] vs −12.9 [n = 249], P =.25) postoperatively. Multivariable analysis showed no difference in weight loss at any time point when adjusting for operation type. Although neoadjuvant GLP-1RAs did not significantly impact weight loss after bariatric surgery, there was an additive weight loss effect. [ABSTRACT FROM AUTHOR] |
| Database: |
Supplemental Index |