| Title: |
Dysglycemia-Based Chronic Disease and Lifestyle Medicine: Mechanistic Interpretation Using the Allostatic Load Model. |
| Authors: |
Bartoskova Polcrova, Anna; Pavlovska, Iuliia; Mechanick, Jeffrey I.; Gonzalez-Rivas, Juan P.; Pikhart, Hynek |
| Source: |
American Journal of Lifestyle Medicine; Mar2026, Vol. 20 Issue 3, p358-365, 8p |
| Subject Terms: |
DIABETES prevention; PREVENTION of chronic diseases; LIFESTYLES; SUBSTANCE abuse; PHYSIOLOGICAL adaptation; SOCIAL determinants of health; BEHAVIOR modification; SEX distribution; BLOOD sugar; MATHEMATICAL models; HEALTH behavior; THEORY; DISEASE progression |
| Abstract: |
Dysglycemia-based chronic disease (DBCD) comprises insulin resistance, prediabetes, and type 2 diabetes, and their staged progression, complications, and impact contribute to one of the largest public health burdens worldwide. The clinical and economic effects of DBCD are fueled by external stressors related to modern society and lifestyles, especially in low socioeconomic strata. Chronic stressor exposure leads to chronic stress, characterized by immune-neuroendocrine activation and mobilization/depletion of metabolic resources. This complex adaptive response engaging many different signaling pathways is termed allostasis and principally regulates homeostatic mechanisms. Allostatic load is the metabolic cost of adaptation to environmental factors and can lead to numerous adverse health outcomes and behaviors. In this narrative review, the bidirectional relationship between allostatic load and unhealthy behaviors is analyzed in the context of DBCD development and progression, with a focus to reduce individual vulnerabilities. [ABSTRACT FROM AUTHOR] |
| : |
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| Database: |
Complementary Index |