| Title: |
Deceased kidney donor cystatin C and subsequent recipient measured glomerular filtration rate at one year after transplantation. |
| Authors: |
Dielwart, Isabelle J. C.; Kremer, Daan; Knobbe, Tim J.; Groothof, Dion; Leuvenink, Henri G. D.; Kootstra-Ros, Jenny E.; de Borst, Martin H.; van Londen, Marco; Sanders, Jan-Stephan F.; Pol, Robert A.; Bakker, Stephan J. L. |
| Source: |
PLoS ONE; 3/10/2026, Vol. 21 Issue 3, p1-11, 11p |
| Subject Terms: |
Cystatin C; Glomerular filtration rate; Organ donation; Kidney function tests; Creatinine; Kidney transplantation |
| Abstract: |
Background: Deceased donor kidney selection is largely determined by creatinine-based kidney function estimation. However, muscle wasting is common in potential donors and affects the accuracy of creatinine-based kidney function assessment. Cystatin C could serve as a muscle-mass independent alternative for this purpose. The primary aim of this study was to evaluate the associations of donor creatinine and cystatin C with recipient measured glomerular filtration (mGFR) at one year after transplantation. Methods: Using data from the prospective TransplantLines study, multivariable linear regression analyses were performed to examine the associations of donor plasma creatinine and cystatin C with recipient I125-iothalamate mGFR. Results: Donor plasma creatinine and cystatin C data were available for 96 donor-recipient pairs. Median pre-donation creatinine and cystatin C concentrations were 56.0 [49.5–71.0] µmol/L and 0.63 [0.50–0.82] mg/L, respectively. Recipient mGFR data at one year after transplantation were available in 55 kidney transplant recipients. Mean recipient mGFR was 52.1 ± 17.0 ml/min. Donor plasma creatinine was not associated with recipient mGFR (st. β −0.19, 95% CI [−0.48 to 0.10], p = 0.21), while donor cystatin C was significantly associated with recipient graft function (st. β −0.52, [−0.83 to −0.21], p = 0.002). The association of cystatin C and recipient mGFR remained materially unchanged after adjustment for potential confounders. Conclusion: In deceased kidney donors, donor plasma creatinine is not associated with recipient mGFR, whereas donor cystatin is associated. Addition of cystatin C to the assessment of deceased kidney donors may provide additional information in difficult cases and improve the accuracy of deceased kidney donor selection. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |