| Title: |
The Effect of Patient Frailty on Morbidity, Mortality and Overall Survival Following Laryngectomy Procedures. |
| Authors: |
Cleere, Eoin F.; Hintze, Justin M.; Brinkman, David; O'Neill, James P.; Timon, Conrad V. I.; Kinsella, John; Lennon, Paul; Fitzgerald, Conall W. R. |
| Source: |
Clinical Otolaryngology; Jan2026, Vol. 51 Issue 1, p40-47, 8p |
| Subject Terms: |
FRAILTY; LARYNGECTOMY; COMORBIDITY; LENGTH of stay in hospitals; POSTOPERATIVE care; MORTALITY; OVERALL survival |
| Abstract: |
Background: The present study evaluated the impact of frailty on patient morbidity and survival following laryngectomy surgery. Methods: A retrospective cohort study of patients undergoing laryngectomy over a 10‐year period. Frailty was measured using the 5‐item modified Frailty Index (5mFI). Results: A total of 233 patients (mean [SD] age, 63.7 [±10.0] years) were included. Eighty‐two (35.2%) patients were frail and frail patients had a greater mean age (66.3 vs. 62.2 years, p = 0.006). On multivariable regression, frail patients were more likely to: develop pharyngocutaneous fistula (OR 2.62, 95% CI 1.33–5.18, p = 0.006), have a longer hospital stay (β 25.53 days, 95% CI 14.64–36.41, p < 0.001) and be discharged to a non‐home setting (OR 5.31, 95% CI 2.49–11.35, p < 0.001). In case‐matched patients, 3‐year overall survival (OS) was similar in frail and not frail patients (p = 0.715). Conclusions: Use of the 5mFI pre‐laryngectomy may identify patients requiring increased support to optimise their peri‐operative risk. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |