| Title: |
Dazukibart for the treatment of severe TIF1γ‐positive juvenile dermatomyositis. |
| Authors: |
Fournier, Benjamin; Sugrue, Jamie; Welfringer‐Morin, Anne; Moreau, Thomas R. J.; Quartier, Pierre; Frémond, Marie‐Louise; Foray, Anne‐Perrine; Tiriau, Soizic; Gitiaux, Cyril; Bondet, Vincent; Rodéro, Mathieu P.; Bodemer, Christine; Duffy, Darragh; Bader‐Meunier, Brigitte |
| Source: |
Journal of the European Academy of Dermatology & Venereology; Apr2026, Vol. 40 Issue 4, pe189-e192, 4p |
| Subject Terms: |
Interferon beta 1b; Monoclonal antibodies; Autoantibodies; Dermatomyositis; Inflammatory mediators; Janus kinases; Muscle strength |
| Abstract: |
This article focuses on the clinical effects of dazukibart, a humanized monoclonal antibody targeting interferon-beta (IFNβ), in treating two patients with severe, anti-TIF1γ-positive juvenile dermatomyositis (JDM) who were refractory to Janus kinase inhibitors (JAKi). Both patients showed rapid and sustained improvement in muscle strength and skin symptoms following dazukibart infusions, with reduced corticosteroid use and no reported side effects. Despite clinical improvement, blood IFNβ levels increased post-treatment, while IFNα levels decreased but remained elevated, and certain inflammatory chemokines (CXCL9, CXCL10, CXCL11) significantly declined. The findings suggest that targeting IFNβ may represent a promising therapeutic approach for severe JDM, highlighting the need for biomarkers to predict treatment response. [Extracted from the article] |
| : |
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| Database: |
Complementary Index |