| Title: |
Molecular evolution of animal aging. |
| Authors: |
Nussey, Daniel H; d'Adda di Fagagna, Fabrizio; Bardin, Allison J; Blau, Helen; Brunet, Anne; Bulavin, Dmitry V; Guo, Longhua; Hara, Eiji; Junker, Jan Philipp; Gorbunova, Vera; Mittelbrunn, Maria; Rera, Michael; Reznick, Jane; Seluanov, Andrei; Schumacher, Björn; Teeling, Emma C; Valenzano, Dario Riccardo; Ye, Jing; Yun, Maximina H; Garinis, George A |
| Source: |
EMBO Journal; Apr2026, Vol. 45 Issue 7, p2095-2111, 17p |
| Subject Terms: |
MOLECULAR evolution; AGING; COMPARATIVE biology; LONGEVITY; ANIMAL models for aging; PHYSIOLOGY; MODEL organisms |
| Abstract: |
Comparative biology plays a crucial role in uncovering fundamental biological mechanisms and providing evolutionary models for their variation. This approach is particularly valuable for studying aging, given the remarkable diversity in aging trajectories across the tree of life. Many evolutionary theories of aging were proposed well before the discovery of the molecular mechanisms involved, and they remain largely theoretical. Moreover, the growing number of model organisms and the expanding array of experimental and theoretical approaches used to study aging have often remained compartmentalized. As a result, integrating these diverse insights into a unified framework has become increasingly important. As a step toward this goal, this field perspective outlines general biological mechanisms that help explain the variability in aging patterns and longevity across the animal kingdom. This field perspective explores the impact of evolution on aging and offers a multi-angle view on longevity variation across animals and environments. [ABSTRACT FROM AUTHOR] |
| : |
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| Database: |
Complementary Index |