| Title: |
Sociodemographic associations with AD biomarkers in POINTER, UBRAIN, and ADNI. |
| Authors: |
Aguilar, Pablo1,2,3 (AUTHOR); Colceriu, Carmen M2 (AUTHOR) carmenmaria.colceriu@isglobal.org; López, Alex2 (AUTHOR); Franquesa‐Mullerat, María4 (AUTHOR); Zsadanyi, Sara E4,5,6,7,8 (AUTHOR); Pérez‐Millan, Agnès9,10,11,12,13,14 (AUTHOR); Farias, Sarah Tomaszewski15,16 (AUTHOR); Tort‐Merino, Adrià14,17,18,19 (AUTHOR); Holland, Thomas Monroe20,21 (AUTHOR); Lockhart, Sam N.22,23 (AUTHOR); Masdeu, Joseph C.24 (AUTHOR); Neumann, Lycia Tramujas Vasconcellos25 (AUTHOR); Valentín, Antonia2 (AUTHOR); Petricola, Sami2 (AUTHOR); Fortea, Juan26,27,28,29 (AUTHOR); Lleó, Alberto4,28,30 (AUTHOR); Snyder, Heather M25 (AUTHOR); Baker, Laura D22,31,32 (AUTHOR); Sánchez‐Valle, Raquel18,33 (AUTHOR); Bejanin, Alexandre27,28,30 (AUTHOR) |
| Source: |
Alzheimer's & Dementia: The Journal of the Alzheimer's Association. Dec2025 Supplement, Vol. 21 Issue S6, p1-4. 4p. |
| Abstract: |
Background: In aging and dementia research, the relationships between modifiable risk factors and biomarkers often vary across cohorts. We aim to evaluate the consistency and generalizability of the association between the area deprivation index (ADI) ‐ an indicator of socioeconomic/resource disadvantage within a specific area ‐ and cognition and Alzheimer's disease (AD) biomarkers across three distinct research cohorts, two from the U.S. (U.S. POINTER Imaging, ADNI) and one from Spain (UBRAIN). Method: We included a total of 3091 participants without dementia, 1879 from U.S. POINTER Imaging, 282 from ADNI and 930 from UBRAIN (Table 1). The ADI was calculated using validated indices from the US and Spain, with neighborhood deprivation ranked as Low, Moderate, and High in the US, and Low and High in Spain. Outcomes of interest included (1) the preclinical Alzheimer's cognitive composite (PACC‐5), (2) MRI‐derived gray matter volumes in AD‐vulnerable regions and (3) PET or CSF‐derived amyloid status (+/‐). We ran logistic regression models with ADI level as predictor adjusted by sex, age, and APOE4 and considered education and race or ethnicity (only US cohorts) in our analyses. Result: Participants in more deprived areas had lower education across cohorts and were more likely to be female (U.S. POINTER) and African American (U.S. POINTER and ADNI, Table 1). Independent of age, sex and APOE4 status, higher ADI was associated with lower PACC in U.S. POINTER (Moderate: β=‐0.165, p |
| Database: |
Supplemental Index |