| Title: |
The Canadian multi‐ethnic research on aging (CAMERA) study: Design, participant characteristics, and preliminary findings. |
| Authors: |
Marawi, Tulip1,2 (AUTHOR); Rai, Harleen1 (AUTHOR); Kumar, Rohina1 (AUTHOR); Vandeloo, Katie L.1,2 (AUTHOR); Yep, Rachel1 (AUTHOR); Alexander, Madeline Wood1,3 (AUTHOR); Boshmaf, Silina Z.1 (AUTHOR); Chen, Sarah‐Mei1 (AUTHOR); Gopinath, Georgia1 (AUTHOR); Malhotra, Simran1 (AUTHOR); Zhang, Angelina1 (AUTHOR); Nyman, Alexander J.1 (AUTHOR); Perri, Lucas Xavier1 (AUTHOR); Sit, Valery1 (AUTHOR); Splinter, Tallinn F. L.1,3 (AUTHOR); Munoz, Douglas P.4,5 (AUTHOR); Swardfager, Walter1,6 (AUTHOR); Ryan, Jennifer D.7 (AUTHOR); Black, Sandra E.1,8 (AUTHOR); Goubran, Maged1,9,10 (AUTHOR) |
| Source: |
Alzheimer's & Dementia: The Journal of the Alzheimer's Association. Apr2026, Vol. 22 Issue 4, p1-13. 13p. |
| Abstract: |
INTRODUCTION: South Asian and Chinese individuals are the largest and fastest‐growing ethnoracial groups in Canada, yet they remain underrepresented in dementia research. To address this gap, we established the CAnadian Multi‐Ethnic Research on Aging (CAMERA) study. METHODS: CAMERA is a longitudinal observational study conducted in Toronto, Canada, enrolling 300 adults aged 55‐85 who self‐identify as South Asian, Chinese, or non‐Hispanic White (NHW). Participants complete in‐person visits at baseline, Year 3, and Year 5, which include clinical and cognitive assessments, brain magnetic resonance imaging (MRI), and blood‐based biomarkers. Annual remote questionnaires track health and lifestyle factors. RESULTS: Among the first 200 participants, vascular and metabolic profiles differed across groups. In addition, South Asian and Chinese participants reported greater cognitive concerns than NHW participants and had lower Montreal Cognitive Assessment (MoCA) scores. The latter was driven primarily by language‐heavy and culturally dependent items. Eye‐tracking measures did not differ across groups. DISCUSSION: CAMERA provides a deep phenotyping framework to investigate dementia risk and resilience factors in Asian Canadians. Highlights: South Asian and Chinese Canadians are rapidly growing populations but remain underrepresented in Alzheimer's disease and related dementias (ADRD) research.CAnadian Multi‐Ethnic Research on Aging (CAMERA) is the first longitudinal deep phenotyping study of ADRD risk and resilience factors in Asian Canadians.South Asian participants showed lower high‐density lipoprotein cholesterol, higher triglycerides, and elevated HbA1c levels compared to non‐Hispanic White (NHW) participants. Chinese participants exhibited higher HbA1c levels compared to NHW participants, despite lower body mass index.South Asian and Chinese participants endorsed greater cognitive concerns than NHW participants and had lower Montreal Cognitive Assessment (MoCA) scores. The latter was driven by items with greater reliance on English proficiency and Western cultural knowledge. [ABSTRACT FROM AUTHOR] |
| Database: |
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